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GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis.
Chauhan D, Demon D, Vande Walle L, Paerewijck O, Zecchin A, Bosseler L, Santoni K, Planès R, Ribo S, Fossoul A, Gonçalves A, Van Gorp H, Van Opdenbosch N, Van Hauwermeiren F, Meunier E, Wullaert A, Lamkanfi M. Chauhan D, et al. EMBO Rep. 2022 Oct 6;23(10):e54277. doi: 10.15252/embr.202154277. Epub 2022 Jul 28. EMBO Rep. 2022. PMID: 35899491 Free PMC article.
Therapeutic modulation of inflammasome pathways.
Chauhan D, Vande Walle L, Lamkanfi M. Chauhan D, et al. Immunol Rev. 2020 Sep;297(1):123-138. doi: 10.1111/imr.12908. Epub 2020 Aug 7. Immunol Rev. 2020. PMID: 32770571 Free PMC article. Review.
Structural basis for the oligomerization-facilitated NLRP3 activation.
Yu X, Matico RE, Miller R, Chauhan D, Van Schoubroeck B, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Van Opdenbosch N, Sharma S. Yu X, et al. Among authors: chauhan d. Nat Commun. 2024 Feb 7;15(1):1164. doi: 10.1038/s41467-024-45396-8. Nat Commun. 2024. PMID: 38326375 Free PMC article.
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A. Roth S, et al. Among authors: chauhan d. Immunity. 2021 Apr 13;54(4):648-659.e8. doi: 10.1016/j.immuni.2021.02.004. Epub 2021 Mar 4. Immunity. 2021. PMID: 33667383 Free article.
Human Monocytes Engage an Alternative Inflammasome Pathway.
Gaidt MM, Ebert TS, Chauhan D, Schmidt T, Schmid-Burgk JL, Rapino F, Robertson AA, Cooper MA, Graf T, Hornung V. Gaidt MM, et al. Among authors: chauhan d. Immunity. 2016 Apr 19;44(4):833-46. doi: 10.1016/j.immuni.2016.01.012. Epub 2016 Mar 29. Immunity. 2016. PMID: 27037191 Free article.
Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.
Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V. Mankan AK, et al. Among authors: chauhan d. EMBO J. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25. EMBO J. 2014. PMID: 25425575 Free PMC article.
924 results