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The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions.
Lee MS, Tuohy PJ, Kim CY, Yost P, Lichauco K, Parrish HL, Van Doorslaer K, Kuhns MS. Lee MS, et al. Among authors: lichauco k. bioRxiv [Preprint]. 2023 Nov 29:2023.05.05.539613. doi: 10.1101/2023.05.05.539613. bioRxiv. 2023. Update in: Elife. 2024 Apr 19;12:RP88225. doi: 10.7554/eLife.88225 PMID: 37214965 Free PMC article. Updated. Preprint.
Enhancing and inhibitory motifs regulate CD4 activity.
Lee MS, Tuohy PJ, Kim CY, Lichauco K, Parrish HL, Van Doorslaer K, Kuhns MS. Lee MS, et al. Among authors: lichauco k. Elife. 2022 Jul 21;11:e79508. doi: 10.7554/eLife.79508. Elife. 2022. PMID: 35861317 Free PMC article.
ADAR1 mutation causes ZBP1-dependent immunopathology.
Hubbard NW, Ames JM, Maurano M, Chu LH, Somfleth KY, Gokhale NS, Werner M, Snyder JM, Lichauco K, Savan R, Stetson DB, Oberst A. Hubbard NW, et al. Among authors: lichauco k. Nature. 2022 Jul;607(7920):769-775. doi: 10.1038/s41586-022-04896-7. Epub 2022 Jul 20. Nature. 2022. PMID: 35859177 Free PMC article.