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Page 1
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M. Krokowski D, et al. Among authors: topisirovic i. Cell Rep. 2022 Jul 19;40(3):111092. doi: 10.1016/j.celrep.2022.111092. Cell Rep. 2022. PMID: 35858571 Free PMC article.
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.
Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N. Dowling RJ, et al. Among authors: topisirovic i. Science. 2010 May 28;328(5982):1172-6. doi: 10.1126/science.1187532. Science. 2010. PMID: 20508131 Free PMC article.
Distinct perturbation of the translatome by the antidiabetic drug metformin.
Larsson O, Morita M, Topisirovic I, Alain T, Blouin MJ, Pollak M, Sonenberg N. Larsson O, et al. Among authors: topisirovic i. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8977-82. doi: 10.1073/pnas.1201689109. Epub 2012 May 18. Proc Natl Acad Sci U S A. 2012. PMID: 22611195 Free PMC article.
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N. Morita M, et al. Among authors: topisirovic i. Mol Cell Biol. 2012 Sep;32(17):3585-93. doi: 10.1128/MCB.00455-12. Epub 2012 Jul 2. Mol Cell Biol. 2012. PMID: 22751931 Free PMC article.
Regulation of mRNA translation by signaling pathways.
Roux PP, Topisirovic I. Roux PP, et al. Among authors: topisirovic i. Cold Spring Harb Perspect Biol. 2012 Nov 1;4(11):a012252. doi: 10.1101/cshperspect.a012252. Cold Spring Harb Perspect Biol. 2012. PMID: 22888049 Free PMC article. Review.
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N. Morita M, et al. Among authors: topisirovic i. Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001. Cell Metab. 2013. PMID: 24206664 Free article.
Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.
Miloslavski R, Cohen E, Avraham A, Iluz Y, Hayouka Z, Kasir J, Mudhasani R, Jones SN, Cybulski N, Rüegg MA, Larsson O, Gandin V, Rajakumar A, Topisirovic I, Meyuhas O. Miloslavski R, et al. Among authors: topisirovic i. J Mol Cell Biol. 2014 Jun;6(3):255-66. doi: 10.1093/jmcb/mju008. Epub 2014 Mar 13. J Mol Cell Biol. 2014. PMID: 24627160 Free PMC article.
134 results