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Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.
Ferguson ID, Lin YT, Lam C, Shao H, Tharp KM, Hale M, Kasap C, Mariano MC, Kishishita A, Patiño Escobar B, Mandal K, Steri V, Wang D, Phojanakong P, Tuomivaara ST, Hann B, Driessen C, Van Ness B, Gestwicki JE, Wiita AP. Ferguson ID, et al. Among authors: lam c. Cell Chem Biol. 2022 Aug 18;29(8):1288-1302.e7. doi: 10.1016/j.chembiol.2022.06.010. Epub 2022 Jul 18. Cell Chem Biol. 2022. PMID: 35853457 Free PMC article.
Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma.
Huang HH, Ferguson ID, Thornton AM, Bastola P, Lam C, Lin YT, Choudhry P, Mariano MC, Marcoulis MD, Teo CF, Malato J, Phojanakong PJ, Martin TG 3rd, Wolf JL, Wong SW, Shah N, Hann B, Brooks AN, Wiita AP. Huang HH, et al. Among authors: lam c. Nat Commun. 2020 Apr 22;11(1):1931. doi: 10.1038/s41467-020-15521-4. Nat Commun. 2020. PMID: 32321912 Free PMC article.
The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma.
Le Moigne R, Aftab BT, Djakovic S, Dhimolea E, Valle E, Murnane M, King EM, Soriano F, Menon MK, Wu ZY, Wong ST, Lee GJ, Yao B, Wiita AP, Lam C, Rice J, Wang J, Chesi M, Bergsagel PL, Kraus M, Driessen C, Kiss von Soly S, Yakes FM, Wustrow D, Shawver L, Zhou HJ, Martin TG 3rd, Wolf JL, Mitsiades CS, Anderson DJ, Rolfe M. Le Moigne R, et al. Among authors: lam c. Mol Cancer Ther. 2017 Nov;16(11):2375-2386. doi: 10.1158/1535-7163.MCT-17-0233. Epub 2017 Sep 6. Mol Cancer Ther. 2017. PMID: 28878026
In-hospital course of patients with heart failure with improved ejection fraction in the DELIVER trial.
Pabon MA, Vaduganathan M, Claggett BL, Chatur S, Siqueira S, Marti-Castellote P, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Jhund PS, McMurray JJV, Solomon SD, Vardeny O. Pabon MA, et al. Among authors: lam csp. Eur J Heart Fail. 2024 Sep 19. doi: 10.1002/ejhf.3410. Online ahead of print. Eur J Heart Fail. 2024. PMID: 39300780
Bench-Stable 2-Halopyridinium Ketene Hemiaminals as Reagents for the Synthesis of 2-Aminopyridine Derivatives.
Bote IC, Krevlin ZA, Crespo MCF, Udomphan S, Levin CT, Lam CC, Glanzer AM, Hutchinson HL, Blades AM, McConnell DL, Lin C, Frank JP, Strutton WR, Merklin JC, Sinardo BA, Gueye KJ, Leiman KV, Thayaparan A, Adade JKA, Martinez NL, Kramer WW, Majireck MM. Bote IC, et al. Among authors: lam cc. Org Lett. 2024 Sep 20. doi: 10.1021/acs.orglett.4c02915. Online ahead of print. Org Lett. 2024. PMID: 39303224
4,815 results