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Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression.
Zagozewski J, Borlase S, Guppy BJ, Coudière-Morrison L, Shahriary GM, Gordon V, Liang L, Cheng S, Porter CJ, Kelley R, Hawkins C, Chan JA, Liang Y, Gong J, Nör C, Saulnier O, Wechsler-Reya RJ, Ramaswamy V, Werbowetski-Ogilvie TE. Zagozewski J, et al. Among authors: porter cj. Commun Biol. 2022 Jul 14;5(1):697. doi: 10.1038/s42003-022-03654-9. Commun Biol. 2022. PMID: 35835937 Free PMC article.
An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate.
Zagozewski J, Shahriary GM, Morrison LC, Saulnier O, Stromecki M, Fresnoza A, Palidwor G, Porter CJ, Forget A, Ayrault O, Hawkins C, Chan JA, Vladoiu MC, Sundaresan L, Arsenio J, Taylor MD, Ramaswamy V, Werbowetski-Ogilvie TE. Zagozewski J, et al. Among authors: porter cj. Nat Commun. 2020 Jul 20;11(1):3627. doi: 10.1038/s41467-020-17357-4. Nat Commun. 2020. PMID: 32686664 Free PMC article.
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing.
Saulnier O, Zagozewski J, Liang L, Hendrikse LD, Layug P, Gordon V, Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Gonzales NM, Palidwor G, Porter CJ, Richard S, Sharif T, Millen KJ, Doble BW, Taylor MD, Werbowetski-Ogilvie TE. Saulnier O, et al. Among authors: porter cj. Nat Cell Biol. 2024 Aug;26(8):1233-1246. doi: 10.1038/s41556-024-01460-5. Epub 2024 Jul 18. Nat Cell Biol. 2024. PMID: 39025928 Free PMC article.
Targeting the MTF2-MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy.
Maganti HB, Jrade H, Cafariello C, Manias Rothberg JL, Porter CJ, Yockell-Lelièvre J, Battaion HL, Khan ST, Howard JP, Li Y, Grzybowski AT, Sabri E, Ruthenburg AJ, Dilworth FJ, Perkins TJ, Sabloff M, Ito CY, Stanford WL. Maganti HB, et al. Among authors: porter cj. Cancer Discov. 2018 Nov;8(11):1376-1389. doi: 10.1158/2159-8290.CD-17-0841. Epub 2018 Aug 16. Cancer Discov. 2018. PMID: 30115703 Free PMC article.
427 results