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141 results

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Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice.
Oblak AL, Kotredes KP, Pandey RS, Reagan AM, Ingraham C, Perkins B, Lloyd C, Baker D, Lin PB, Soni DM, Tsai AP, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Meyer JA, Peters JS, Figueiredo LL, Sasner M, Territo PR, Sukoff Rizzo SJ, Carter GW, Lamb BT, Howell GR. Oblak AL, et al. Among authors: lamb bt. Front Aging Neurosci. 2022 Jun 24;14:886575. doi: 10.3389/fnagi.2022.886575. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35813947 Free PMC article.
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. Jay TR, et al. Among authors: lamb bt. J Exp Med. 2015 Mar 9;212(3):287-95. doi: 10.1084/jem.20142322. Epub 2015 Mar 2. J Exp Med. 2015. PMID: 25732305 Free PMC article.
Improving preclinical to clinical translation in Alzheimer's disease research.
Sukoff Rizzo SJ, Masters A, Onos KD, Quinney S, Sasner M, Oblak A, Lamb BT, Territo PR; MODEL‐AD consortium. Sukoff Rizzo SJ, et al. Among authors: lamb bt. Alzheimers Dement (N Y). 2020 Jun 14;6(1):e12038. doi: 10.1002/trc2.12038. eCollection 2020. Alzheimers Dement (N Y). 2020. PMID: 32548237 Free PMC article.
Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.
Jadhav VS, Lin PBC, Pennington T, Di Prisco GV, Jannu AJ, Xu G, Moutinho M, Zhang J, Atwood BK, Puntambekar SS, Bissel SJ, Oblak AL, Landreth GE, Lamb BT. Jadhav VS, et al. Among authors: lamb bt. Mol Neurodegener. 2020 Oct 28;15(1):62. doi: 10.1186/s13024-020-00409-0. Mol Neurodegener. 2020. PMID: 33115519 Free PMC article.
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease.
Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, Garceau D, Kotredes KP, Williams H, Mangravite LM, Lamb BT, Oblak AL, Howell GR, Sasner M, Logsdon BA; MODEL-AD Consortium; Carter GW. Preuss C, et al. Among authors: lamb bt. Mol Neurodegener. 2020 Nov 10;15(1):67. doi: 10.1186/s13024-020-00412-5. Mol Neurodegener. 2020. PMID: 33172468 Free PMC article.
Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD.
Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, LaFerla FM, Lamb BT; and The MODEL‐AD; Consortium. Oblak AL, et al. Among authors: lamb bt. Alzheimers Dement (N Y). 2020 Nov 23;6(1):e12110. doi: 10.1002/trc2.12110. eCollection 2020. Alzheimers Dement (N Y). 2020. PMID: 33283040 Free PMC article.
Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank.
Vitek MP, Araujo JA, Fossel M, Greenberg BD, Howell GR, Rizzo SJS, Seyfried NT, Tenner AJ, Territo PR, Windisch M, Bain LJ, Ross A, Carrillo MC, Lamb BT, Edelmayer RM. Vitek MP, et al. Among authors: lamb bt. Alzheimers Dement (N Y). 2021 Jan 11;6(1):e12114. doi: 10.1002/trc2.12114. eCollection 2020. Alzheimers Dement (N Y). 2021. PMID: 33457489 Free PMC article.
Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.
Oblak AL, Lin PB, Kotredes KP, Pandey RS, Garceau D, Williams HM, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarczyk D, Belanger M, Cope ZA, Little GJ, Williams SG, Ash C, Bleckert A, Ragan T, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Howell GR, Sasner M, Lamb BT. Oblak AL, et al. Among authors: lamb bt. Front Aging Neurosci. 2021 Jul 23;13:713726. doi: 10.3389/fnagi.2021.713726. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34366832 Free PMC article.
Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H.
Kotredes KP, Oblak A, Pandey RS, Lin PB, Garceau D, Williams H, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarycek D, Belanger M, Cope Z, Foley KE, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Sasner M, Lamb BT, Howell GR. Kotredes KP, et al. Among authors: lamb bt. Front Aging Neurosci. 2021 Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34707490 Free PMC article.
141 results