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Whole-Body PET Imaging in Humans Shows That 11C-PS13 Is Selective for Cyclooxygenase-1 and Can Measure the In Vivo Potency of Nonsteroidal Antiinflammatory Drugs.
Kim MJ, Anaya FJ, Manly LS, Lee JH, Hong J, Shrestha S, Telu S, Henry K, Santamaria JAM, Liow JS, Zanotti-Fregonara P, Shetty HU, Zoghbi SS, Pike VW, Innis RB. Kim MJ, et al. J Nucl Med. 2023 Jan;64(1):159-164. doi: 10.2967/jnumed.122.264061. Epub 2022 Jul 7. J Nucl Med. 2023. PMID: 35798558 Free PMC article.
3-Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [11C]PS13 for Quantitative Imaging.
Shrestha S, Singh P, Cortes-Salva MY, Jenko KJ, Ikawa M, Kim MJ, Kobayashi M, Morse CL, Gladding RL, Liow JS, Zoghbi SS, Fujita M, Innis RB, Pike VW. Shrestha S, et al. Among authors: kim mj. ACS Chem Neurosci. 2018 Nov 21;9(11):2620-2627. doi: 10.1021/acschemneuro.8b00103. Epub 2018 Jun 13. ACS Chem Neurosci. 2018. PMID: 29792035 Free PMC article.
PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study.
Shrestha S, Kim MJ, Eldridge M, Lehmann ML, Frankland M, Liow JS, Yu ZX, Cortes-Salva M, Telu S, Henter ID, Gallagher E, Lee JH, Fredericks JM, Poffenberger C, Tye G, Ruiz-Perdomo Y, Anaya FJ, Montero Santamaria JA, Gladding RL, Zoghbi SS, Fujita M, Katz JD, Pike VW, Innis RB. Shrestha S, et al. Among authors: kim mj. J Neuroinflammation. 2020 May 2;17(1):140. doi: 10.1186/s12974-020-01804-6. J Neuroinflammation. 2020. PMID: 32359360 Free PMC article. Clinical Trial.
First-in-human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain.
Kim MJ, Lee JH, Juarez Anaya F, Hong J, Miller W, Telu S, Singh P, Cortes MY, Henry K, Tye GL, Frankland MP, Montero Santamaria JA, Liow JS, Zoghbi SS, Fujita M, Pike VW, Innis RB. Kim MJ, et al. Eur J Nucl Med Mol Imaging. 2020 Dec;47(13):3143-3151. doi: 10.1007/s00259-020-04855-2. Epub 2020 May 12. Eur J Nucl Med Mol Imaging. 2020. PMID: 32399622 Free PMC article.
PET imaging of neuroinflammation in neurological disorders.
Kreisl WC, Kim MJ, Coughlin JM, Henter ID, Owen DR, Innis RB. Kreisl WC, et al. Among authors: kim mj. Lancet Neurol. 2020 Nov;19(11):940-950. doi: 10.1016/S1474-4422(20)30346-X. Lancet Neurol. 2020. PMID: 33098803 Free PMC article. Review.
Synthesis of [18F]PS13 and Evaluation as a PET Radioligand for Cyclooxygenase-1 in Monkey.
Taddei C, Morse CL, Kim MJ, Liow JS, Montero Santamaria J, Zhang A, Manly LS, Zanotti-Fregonara P, Gladding RL, Zoghbi SS, Innis RB, Pike VW. Taddei C, et al. Among authors: kim mj. ACS Chem Neurosci. 2021 Feb 3;12(3):517-530. doi: 10.1021/acschemneuro.0c00737. Epub 2021 Jan 25. ACS Chem Neurosci. 2021. PMID: 33491441 Free PMC article.
[11C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain.
Ghazanfari N, Liow JS, Kim MJ, Cureton R, Lee A, Knoer C, Jenkins M, Hong J, Santamaria JAM, Shetty HU, Galassi A, Wighton P, Nørgaard M, Greve DN, Zoghbi SS, Pike VW, Innis RB, Zanotti-Fregonara P. Ghazanfari N, et al. Among authors: kim mj. J Nucl Med. 2024 Nov 14:jnumed.124.267928. doi: 10.2967/jnumed.124.267928. Online ahead of print. J Nucl Med. 2024. PMID: 39542698
9,140 results