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Chlorambucil-conjugated PI-polyamides (Chb-M'), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation.
Matsui Y, Mineharu Y, Noguchi Y, Hattori EY, Kubota H, Hirata M, Miyamoto S, Sugiyama H, Arakawa Y, Kamikubo Y. Matsui Y, et al. Among authors: sugiyama h. Biochem Biophys Res Commun. 2022 Sep 10;620:150-157. doi: 10.1016/j.bbrc.2022.06.090. Epub 2022 Jun 28. Biochem Biophys Res Commun. 2022. PMID: 35792512
Genetic regulation of the RUNX transcription factor family has antitumor effects.
Morita K, Suzuki K, Maeda S, Matsuo A, Mitsuda Y, Tokushige C, Kashiwazaki G, Taniguchi J, Maeda R, Noura M, Hirata M, Kataoka T, Yano A, Yamada Y, Kiyose H, Tokumasu M, Matsuo H, Tanaka S, Okuno Y, Muto M, Naka K, Ito K, Kitamura T, Kaneda Y, Liu PP, Bando T, Adachi S, Sugiyama H, Kamikubo Y. Morita K, et al. Among authors: sugiyama h. J Clin Invest. 2017 Jun 30;127(7):2815-2828. doi: 10.1172/JCI91788. Epub 2017 May 22. J Clin Invest. 2017. PMID: 28530640 Free PMC article.
Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells.
Morita K, Noura M, Tokushige C, Maeda S, Kiyose H, Kashiwazaki G, Taniguchi J, Bando T, Yoshida K, Ozaki T, Matsuo H, Ogawa S, Liu PP, Nakahata T, Sugiyama H, Adachi S, Kamikubo Y. Morita K, et al. Among authors: sugiyama h. Sci Rep. 2017 Nov 30;7(1):16604. doi: 10.1038/s41598-017-16799-z. Sci Rep. 2017. PMID: 29192243 Free PMC article.
Suppression of malignant rhabdoid tumors through Chb-M'-mediated RUNX1 inhibition.
Daifu T, Mikami M, Hiramatsu H, Iwai A, Umeda K, Noura M, Kubota H, Masuda T, Furuichi K, Takasaki S, Noguchi Y, Morita K, Bando T, Hirata M, Kataoka TR, Nakahata T, Kuwahara Y, Iehara T, Hosoi H, Takita J, Sugiyama H, Adachi S, Kamikubo Y. Daifu T, et al. Among authors: sugiyama h. Pediatr Blood Cancer. 2021 Feb;68(2):e28789. doi: 10.1002/pbc.28789. Epub 2020 Nov 12. Pediatr Blood Cancer. 2021. PMID: 33180377
2,735 results