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Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1.
Feng Z, Hom ME, Bearrood TE, Rosenthal ZC, Fernández D, Ondrus AE, Gu Y, McCormick AK, Tomaske MG, Marshall CR, Kline T, Chen CH, Mochly-Rosen D, Kuo CJ, Chen JK. Feng Z, et al. Among authors: chen jk, chen ch. Nat Chem Biol. 2022 Oct;18(10):1065-1075. doi: 10.1038/s41589-022-01048-w. Epub 2022 Jul 4. Nat Chem Biol. 2022. PMID: 35788181 Free PMC article.
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. Firestone AJ, et al. Among authors: chen jk. Nature. 2012 Mar 18;484(7392):125-9. doi: 10.1038/nature10936. Nature. 2012. PMID: 22425997 Free PMC article.
Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.
Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM. Steinman JB, et al. Among authors: chen jk. Elife. 2017 May 19;6:e25174. doi: 10.7554/eLife.25174. Elife. 2017. PMID: 28524820 Free PMC article.
Small-molecule regulation of zebrafish gene expression.
Esengil H, Chang V, Mich JK, Chen JK. Esengil H, et al. Among authors: chen jk. Nat Chem Biol. 2007 Mar;3(3):154-5. doi: 10.1038/nchembio858. Epub 2007 Jan 21. Nat Chem Biol. 2007. PMID: 17237798
Light-controlled gene silencing in zebrafish embryos.
Shestopalov IA, Sinha S, Chen JK. Shestopalov IA, et al. Among authors: chen jk. Nat Chem Biol. 2007 Oct;3(10):650-1. doi: 10.1038/nchembio.2007.30. Epub 2007 Aug 23. Nat Chem Biol. 2007. PMID: 17717538
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. Hyman JM, et al. Among authors: chen jk. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7. doi: 10.1073/pnas.0907134106. Epub 2009 Aug 5. Proc Natl Acad Sci U S A. 2009. PMID: 19666565 Free PMC article.
1,016 results