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Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate.
Freire MCLC, Basso LGM, Mendes LFS, Mesquita NCMR, Mottin M, Fernandes RS, Policastro LR, Godoy AS, Santos IA, Ruiz UEA, Caruso IP, Sousa BKP, Jardim ACG, Almeida FCL, Gil LHVG, Andrade CH, Oliva G. Freire MCLC, et al. Among authors: ruiz uea. Sci Rep. 2022 Jun 22;12(1):10601. doi: 10.1038/s41598-022-14790-x. Sci Rep. 2022. PMID: 35732685 Free PMC article.
The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication.
Policastro LR, Dolci I, Godoy AS, Silva Júnior JVJ, Ruiz UEA, Santos IA, Jardim ACG, Samby K, Burrows JN, Wells TNC, Gil LHVG, Oliva G, Fernandes RS. Policastro LR, et al. Among authors: ruiz uea. Viruses. 2022 Jun 21;14(7):1351. doi: 10.3390/v14071351. Viruses. 2022. PMID: 35891332 Free PMC article.
Imidazonaphthyridine effects on Chikungunya virus replication: Antiviral activity by dependent and independent of interferon type 1 pathways.
Ruiz UEA, Santos IA, Grosche VR, Fernandes RS, de Godoy AS, Torres JDA, Freire MCLC, Mesquita NCMR, Guevara-Vega M, Nicolau-Junior N, Sabino-Silva R, Mineo TWP, Oliva G, Jardim ACG. Ruiz UEA, et al. Virus Res. 2023 Jan 15;324:199029. doi: 10.1016/j.virusres.2022.199029. Epub 2022 Dec 22. Virus Res. 2023. PMID: 36565816 Free PMC article.