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Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions.
Hepokoski ML, Odish M, Lam MT, Coufal NG, Rolfsen ML, Shadel GS, Moyzis AG, Sainz AG, Takiar PG, Patel S, Leonard AJ, Samandari N, Hansen E, Trescott S, Nguyen C, Jepsen K, Cutter G, Gillespie MN, Spragg RG, Sasik R, Ix JH. Hepokoski ML, et al. Among authors: shadel gs. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L84-L92. doi: 10.1152/ajplung.00128.2022. Epub 2022 Jun 14. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35699291 Free PMC article.
Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.
Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Wu Z, et al. Among authors: shadel gs. Nat Metab. 2019 Dec;1(12):1209-1218. doi: 10.1038/s42255-019-0150-8. Epub 2019 Dec 9. Nat Metab. 2019. PMID: 32395698 Free PMC article.
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.
Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. Lei Y, et al. Among authors: shadel gs. Circ Res. 2021 Apr 30;128(9):1323-1326. doi: 10.1161/CIRCRESAHA.121.318902. Epub 2021 Mar 31. Circ Res. 2021. PMID: 33784827 Free PMC article. No abstract available.
Mitochondrial DNA: cellular genotoxic stress sentinel.
Wu Z, Sainz AG, Shadel GS. Wu Z, et al. Among authors: shadel gs. Trends Biochem Sci. 2021 Oct;46(10):812-821. doi: 10.1016/j.tibs.2021.05.004. Epub 2021 Jun 1. Trends Biochem Sci. 2021. PMID: 34088564 Free PMC article. Review.
Manipulating mitochondrial electron flow enhances tumor immunogenicity.
Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. Mangalhara KC, et al. Among authors: shadel gs. Science. 2023 Sep 22;381(6664):1316-1323. doi: 10.1126/science.abq1053. Epub 2023 Sep 21. Science. 2023. PMID: 37733872 Free PMC article.
Accessorizing the human mitochondrial transcription machinery.
Bestwick ML, Shadel GS. Bestwick ML, et al. Among authors: shadel gs. Trends Biochem Sci. 2013 Jun;38(6):283-91. doi: 10.1016/j.tibs.2013.03.006. Epub 2013 Apr 27. Trends Biochem Sci. 2013. PMID: 23632312 Free PMC article. Review.
Expanding the mitochondrial interactome.
Shutt TE, Shadel GS. Shutt TE, et al. Among authors: shadel gs. Genome Biol. 2007;8(2):203. doi: 10.1186/gb-2007-8-2-203. Genome Biol. 2007. PMID: 17319976 Free PMC article. Review.
149 results