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Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals.
Bozhanova NG, Flyak AI, Brown BP, Ruiz SE, Salas J, Rho S, Bombardi RG, Myers L, Soto C, Bailey JR, Crowe JE Jr, Bjorkman PJ, Meiler J. Bozhanova NG, et al. Among authors: meiler j. Nat Commun. 2022 Jun 8;13(1):3178. doi: 10.1038/s41467-022-30865-9. Nat Commun. 2022. PMID: 35676279 Free PMC article. Review.
Human germline antibody gene segments encode polyspecific antibodies.
Willis JR, Briney BS, DeLuca SL, Crowe JE Jr, Meiler J. Willis JR, et al. Among authors: meiler j. PLoS Comput Biol. 2013 Apr;9(4):e1003045. doi: 10.1371/journal.pcbi.1003045. Epub 2013 Apr 25. PLoS Comput Biol. 2013. PMID: 23637590 Free PMC article.
Human rotavirus VP6-specific antibodies mediate intracellular neutralization by binding to a quaternary structure in the transcriptional pore.
Aiyegbo MS, Sapparapu G, Spiller BW, Eli IM, Williams DR, Kim R, Lee DE, Liu T, Li S, Woods VL Jr, Nannemann DP, Meiler J, Stewart PL, Crowe JE Jr. Aiyegbo MS, et al. Among authors: meiler j. PLoS One. 2013 May 9;8(5):e61101. doi: 10.1371/journal.pone.0061101. Print 2013. PLoS One. 2013. PMID: 23671563 Free PMC article.
Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.
Willis JR, Sapparapu G, Murrell S, Julien JP, Singh V, King HG, Xia Y, Pickens JA, LaBranche CC, Slaughter JC, Montefiori DC, Wilson IA, Meiler J, Crowe JE Jr. Willis JR, et al. Among authors: meiler j. J Clin Invest. 2015 Jun;125(6):2523-31. doi: 10.1172/JCI80693. Epub 2015 May 18. J Clin Invest. 2015. PMID: 25985274 Free PMC article.
Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Mousa JJ, Sauer MF, Sevy AM, Finn JA, Bates JT, Alvarado G, King HG, Loerinc LB, Fong RH, Doranz BJ, Correia BE, Kalyuzhniy O, Wen X, Jardetzky TS, Schief WR, Ohi MD, Meiler J, Crowe JE Jr. Mousa JJ, et al. Among authors: meiler j. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6849-E6858. doi: 10.1073/pnas.1609449113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791117 Free PMC article.
449 results