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Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague.
Jakielaszek C, Hossain M, Qian L, Fishman C, Widdowson K, Hilliard JJ, Mannino F, Raychaudhuri A, Carniel E, Demons S, Heine HS, Hershfield J, Russo R, Mega WM, Revelli D, O'Dwyer K. Jakielaszek C, et al. Among authors: russo r. Sci Transl Med. 2022 Jun;14(647):eabg1787. doi: 10.1126/scitranslmed.abg1787. Epub 2022 Jun 1. Sci Transl Med. 2022. PMID: 35648812
Efficacy of therapeutically administered gepotidacin in a rabbit model of inhalational anthrax.
Hilliard JJ, Jakielaszek C, Mannino F, Hossain M, Qian L, Fishman C, Demons S, Hershfield J, Soffler C, Russo R, Henning L, Novak J, O'Dwyer K. Hilliard JJ, et al. Among authors: russo r. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0149723. doi: 10.1128/aac.01497-23. Epub 2024 Feb 15. Antimicrob Agents Chemother. 2024. PMID: 38358266 Free PMC article.
A Novel Oral GyrB/ParE Dual Binding Inhibitor Effective against Multidrug-Resistant Neisseria gonorrhoeae and Other High-Threat Pathogens.
Park S, Russo R, Westfall L, Shrestha R, Zimmerman M, Dartois V, Kurepina N, Kreiswirth B, Singleton E, Li SG, Mittal N, Ahn YM, Bilotta J, Connolly KL, Jerse AE, Freundlich JS, Perlin DS. Park S, et al. Among authors: russo r. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0041422. doi: 10.1128/aac.00414-22. Epub 2022 Aug 16. Antimicrob Agents Chemother. 2022. PMID: 35972242 Free PMC article.
Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent.
Gallardo-Macias R, Kumar P, Jaskowski M, Richmann T, Shrestha R, Russo R, Singleton E, Zimmerman MD, Ho HP, Dartois V, Connell N, Alland D, Freundlich JS. Gallardo-Macias R, et al. Among authors: russo r. Bioorg Med Chem Lett. 2019 Feb 15;29(4):601-606. doi: 10.1016/j.bmcl.2018.12.053. Epub 2018 Dec 24. Bioorg Med Chem Lett. 2019. PMID: 30600207 Free PMC article.
A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.
Inoyama D, Awasthi D, Capodagli GC, Tsotetsi K, Sukheja P, Zimmerman M, Li SG, Jadhav R, Russo R, Wang X, Grady C, Richmann T, Shrestha R, Li L, Ahn YM, Ho Liang HP, Mina M, Park S, Perlin DS, Connell N, Dartois V, Alland D, Neiditch MB, Kumar P, Freundlich JS. Inoyama D, et al. Among authors: russo r. Cell Chem Biol. 2020 May 21;27(5):560-570.e10. doi: 10.1016/j.chembiol.2020.02.007. Epub 2020 Mar 19. Cell Chem Biol. 2020. PMID: 32197094 Free PMC article.
Small Molecule Benzothiophene with In Vivo Efficacy in a Mouse Model of Drug-Resistant Enterococcus faecium Infection.
Gallardo-Macias R, Russo R, Sherwood M, Jaskowski M, Nasser W, Sharma P, Tuckman M, Singleton E, Ho HP, Park S, Patel JS, George A, Perlin D, Zimmerman MD, Connell N, Freundlich JS. Gallardo-Macias R, et al. Among authors: russo r. J Med Chem. 2024 Jan 25;67(2):1384-1392. doi: 10.1021/acs.jmedchem.3c01846. Epub 2024 Jan 15. J Med Chem. 2024. PMID: 38225186
Naïve Bayesian Models for Vero Cell Cytotoxicity.
Perryman AL, Patel JS, Russo R, Singleton E, Connell N, Ekins S, Freundlich JS. Perryman AL, et al. Among authors: russo r. Pharm Res. 2018 Jun 29;35(9):170. doi: 10.1007/s11095-018-2439-9. Pharm Res. 2018. PMID: 29959603 Free PMC article.
2,189 results