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Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.
Guimond SE, Mycroft-West CJ, Gandhi NS, Tree JA, Le TT, Spalluto CM, Humbert MV, Buttigieg KR, Coombes N, Elmore MJ, Wand M, Nyström K, Said J, Setoh YX, Amarilla AA, Modhiran N, Sng JDJ, Chhabra M, Young PR, Rawle DJ, Lima MA, Yates EA, Karlsson R, Miller RL, Chen YH, Bagdonaite I, Yang Z, Stewart J, Nguyen D, Laidlaw S, Hammond E, Dredge K, Wilkinson TMA, Watterson D, Khromykh AA, Suhrbier A, Carroll MW, Trybala E, Bergström T, Ferro V, Skidmore MA, Turnbull JE. Guimond SE, et al. Among authors: modhiran n. ACS Cent Sci. 2022 May 25;8(5):527-545. doi: 10.1021/acscentsci.1c01293. Epub 2022 Mar 29. ACS Cent Sci. 2022. PMID: 35647275 Free PMC article.
Response to comment on "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity" and "Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination".
Stacey KJ, Watterson D, Modhiran N, Young PR. Stacey KJ, et al. Among authors: modhiran n. Sci Transl Med. 2015 Dec 16;7(318):318lr4. doi: 10.1126/scitranslmed.aad8657. Sci Transl Med. 2015. PMID: 26676606
Riboflavin and ultraviolet light: impact on dengue virus infectivity.
Faddy HM, Fryk JJ, Watterson D, Young PR, Modhiran N, Muller DA, Keil SD, Goodrich RP, Marks DC. Faddy HM, et al. Among authors: modhiran n. Vox Sang. 2016 Oct;111(3):235-241. doi: 10.1111/vox.12414. Epub 2016 Jun 9. Vox Sang. 2016. PMID: 27281512
Plugging the Leak in Dengue Shock.
Watterson D, Modhiran N, Muller DA, Stacey KJ, Young PR. Watterson D, et al. Among authors: modhiran n. Adv Exp Med Biol. 2018;1062:89-106. doi: 10.1007/978-981-10-8727-1_7. Adv Exp Med Biol. 2018. PMID: 29845527 Review.
CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain.
Amarilla AA, Santos-Junior NN, Figueiredo ML, Luiz JPM, Fumagalli MJ, Colón DF, Lippi V, Alfonso HL, Lima-Junior DS, Trabuco AC, Spinieli RL, Desidera AC, Leite-Panissi CRA, Lauretti F, Mendoza SES, Silva CLA, Rego EM, Galvao-Lima LJ, Bassi GS, Penharvel Martíns SLB, Manrique WG, Alves-Filho JC, Cunha FQ, Peng NYG, Modhiran N, Setoh YX, Khromykh AA, Figueiredo LTM, Aquino VH. Amarilla AA, et al. Among authors: modhiran n. J Infect Dis. 2019 May 24;219(12):2015-2025. doi: 10.1093/infdis/jiz029. J Infect Dis. 2019. PMID: 30715407 Free PMC article.
Determinants of Zika virus host tropism uncovered by deep mutational scanning.
Setoh YX, Amarilla AA, Peng NYG, Griffiths RE, Carrera J, Freney ME, Nakayama E, Ogawa S, Watterson D, Modhiran N, Nanyonga FE, Torres FJ, Slonchak A, Periasamy P, Prow NA, Tang B, Harrison J, Hobson-Peters J, Cuddihy T, Cooper-White J, Hall RA, Young PR, Mackenzie JM, Wolvetang E, Bloom JD, Suhrbier A, Khromykh AA. Setoh YX, et al. Among authors: modhiran n. Nat Microbiol. 2019 May;4(5):876-887. doi: 10.1038/s41564-019-0399-4. Epub 2019 Mar 18. Nat Microbiol. 2019. PMID: 30886357 Free PMC article.
Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon.
Tan YP, Houston SD, Modhiran N, Savchenko AI, Boyle GM, Young PR, Watterson D, Williams CM. Tan YP, et al. Among authors: modhiran n. Chemistry. 2019 Apr 17;25(22):5664-5667. doi: 10.1002/chem.201900591. Epub 2019 Mar 29. Chemistry. 2019. PMID: 30924209
62 results