Chen L - Search Results

1

Pan-cancer pervasive upregulation of 3' UTR splicing drives tumourigenesis.

Chan JJ, Zhang B, Chew XH, Salhi A, Kwok ZH, Lim CY, Desi N, Subramaniam N, Siemens A, Kinanti T, Ong S, Sanchez-Mejias A, Ly PT, An O, Sundar R, Fan X, Wang S, Siew BE, Lee KC, Chong CS, Lieske B, Cheong WK, Goh Y, Fam WN, Ooi MG, Koh BTH, Iyer SG, Ling WH, Chen J, Yoong BK, Chanwat R, Bonney GK, Goh BKP, Zhai W, Fullwood MJ, Wang W, Tan KK, Chng WJ, Dan YY, Pitt JJ, Roca X, Guccione E, Vardy LA, Chen L, Gao X, Chow PKH, Yang H, Tay Y. Chan JJ, et al. Among authors: chen j, chen l. Nat Cell Biol. 2022 Jun;24(6):928-939. doi: 10.1038/s41556-022-00913-z. Epub 2022 May 26. Nat Cell Biol. 2022. PMID: 35618746 Free PMC article.

2

An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer.

Qi L, Song Y, Chan THM, Yang H, Lin CH, Tay DJT, Hong H, Tang SJ, Tan KT, Huang XX, Lin JS, Ng VHE, Maury JJP, Tenen DG, Chen L. Qi L, et al. Among authors: chen l. Nucleic Acids Res. 2017 Oct 13;45(18):10436-10451. doi: 10.1093/nar/gkx667. Nucleic Acids Res. 2017. PMID: 28985428 Free PMC article.

3

Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer.

Hong H, An O, Chan THM, Ng VHE, Kwok HS, Lin JS, Qi L, Han J, Tay DJT, Tang SJ, Yang H, Song Y, Bellido Molias F, Tenen DG, Chen L. Hong H, et al. Among authors: chen l. Nucleic Acids Res. 2018 Sep 6;46(15):7953-7969. doi: 10.1093/nar/gky396. Nucleic Acids Res. 2018. PMID: 29796672 Free PMC article.

4

Aberrant hyperediting of the myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis.

Teoh PJ, An O, Chung TH, Chooi JY, Toh SHM, Fan S, Wang W, Koh BTH, Fullwood MJ, Ooi MG, de Mel S, Soekojo CY, Chen L, Ng SB, Yang H, Chng WJ. Teoh PJ, et al. Among authors: chen l. Blood. 2018 Sep 20;132(12):1304-1317. doi: 10.1182/blood-2018-02-832576. Epub 2018 Jul 30. Blood. 2018. PMID: 30061158 Free article.

5

Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development.

Tang SJ, Shen H, An O, Hong H, Li J, Song Y, Han J, Tay DJT, Ng VHE, Bellido Molias F, Leong KW, Pitcheshwar P, Yang H, Chen L. Tang SJ, et al. Among authors: chen l. Nat Commun. 2020 Feb 7;11(1):799. doi: 10.1038/s41467-020-14621-5. Nat Commun. 2020. PMID: 32034135 Free PMC article.

6

CSI NGS Portal: An Online Platform for Automated NGS Data Analysis and Sharing.

An O, Tan KT, Li Y, Li J, Wu CS, Zhang B, Chen L, Yang H. An O, et al. Among authors: chen l. Int J Mol Sci. 2020 May 28;21(11):3828. doi: 10.3390/ijms21113828. Int J Mol Sci. 2020. PMID: 32481589 Free PMC article.

7

Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression.

Han J, An O, Hong H, Chan THM, Song Y, Shen H, Tang SJ, Lin JS, Ng VHE, Tay DJT, Molias FB, Pitcheshwar P, Tan HQ, Yang H, Chen L. Han J, et al. Among authors: chen l. Sci Adv. 2020 Jun 17;6(25):eaba5136. doi: 10.1126/sciadv.aba5136. eCollection 2020 Jun. Sci Adv. 2020. PMID: 32596459 Free PMC article.

8

RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis.

Song Y, An O, Ren X, Chan THM, Tay DJT, Tang SJ, Han J, Hong H, Ng VHE, Ke X, Shen H, Pitcheshwar P, Lin JS, Leong KW, Molias FB, Yang H, Kappei D, Chen L. Song Y, et al. Among authors: chen l. J Hepatol. 2021 Jan;74(1):135-147. doi: 10.1016/j.jhep.2020.07.021. Epub 2020 Jul 18. J Hepatol. 2021. PMID: 32693003 Free article.

9

"3G" Trial: An RNA Editing Signature to Guide Gastric Cancer Chemotherapy.

An O, Song Y, Ke X, So JB, Sundar R, Yang H, Rha SY, Lee MH, Tay ST, Ong X, Tan ALK, Ng MCH, Tantoso E, Chen L, Tan P, Yong WP; Singapore Gastric Cancer Consortium (SGCC). An O, et al. Among authors: chen l. Cancer Res. 2021 May 15;81(10):2788-2798. doi: 10.1158/0008-5472.CAN-20-2872. Epub 2021 Feb 8. Cancer Res. 2021. PMID: 33558338

10

Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer.

Tay DJT, Song Y, Peng B, Toh TB, Hooi L, Toh DK, Hong H, Tang SJ, Han J, Gan WL, Chan THM, Krishna MS, Patil KM, Maraswami M, Loh TP, Dan YY, Zhou L, Bonney GK, Chow PK, Chen G, Chow EK, Le MTN, Chen L. Tay DJT, et al. Among authors: chen l, chen g. Mol Ther. 2021 Nov 3;29(11):3258-3273. doi: 10.1016/j.ymthe.2021.05.008. Epub 2021 May 8. Mol Ther. 2021. PMID: 33974998 Free PMC article.

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