Hoxhaj G - Search Results

1

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.

Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G. Soflaee MH, et al. Among authors: hoxhaj g. Nat Commun. 2022 May 16;13(1):2698. doi: 10.1038/s41467-022-30362-z. Nat Commun. 2022. PMID: 35577785 Free PMC article.

2

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.

Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Menon S, et al. Among authors: hoxhaj g. Cell. 2014 Feb 13;156(4):771-85. doi: 10.1016/j.cell.2013.11.049. Cell. 2014. PMID: 24529379 Free PMC article.

3

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD. Ben-Sahra I, et al. Among authors: hoxhaj g. Science. 2016 Feb 12;351(6274):728-733. doi: 10.1126/science.aad0489. Science. 2016. PMID: 26912861 Free PMC article.

4

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

Heintz C, Doktor TK, Lanjuin A, Escoubas C, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB. Heintz C, et al. Among authors: hoxhaj g. Nature. 2017 Jan 5;541(7635):102-106. doi: 10.1038/nature20789. Epub 2016 Dec 5. Nature. 2017. PMID: 27919065 Free PMC article.

5

Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.

Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. Howell JJ, et al. Among authors: hoxhaj g. Cell Metab. 2017 Feb 7;25(2):463-471. doi: 10.1016/j.cmet.2016.12.009. Epub 2017 Jan 12. Cell Metab. 2017. PMID: 28089566 Free PMC article.

6

Corrigendum: Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

Heintz C, Doktor TK, Lanjuin A, Escoubas CC, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB. Heintz C, et al. Among authors: hoxhaj g. Nature. 2017 Jul 27;547(7664):476. doi: 10.1038/nature23313. Epub 2017 Jul 12. Nature. 2017. PMID: 28700577

7

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD. Hoxhaj G, et al. Cell Rep. 2017 Oct 31;21(5):1331-1346. doi: 10.1016/j.celrep.2017.10.029. Cell Rep. 2017. PMID: 29091770 Free PMC article.

8

Direct stimulation of NADP⁺ synthesis through Akt-mediated phosphorylation of NAD kinase.

Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Hoxhaj G, et al. Science. 2019 Mar 8;363(6431):1088-1092. doi: 10.1126/science.aau3903. Science. 2019. PMID: 30846598 Free PMC article.

9

The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism.

Hoxhaj G, Manning BD. Hoxhaj G, et al. Nat Rev Cancer. 2020 Feb;20(2):74-88. doi: 10.1038/s41568-019-0216-7. Epub 2019 Nov 4. Nat Rev Cancer. 2020. PMID: 31686003 Free PMC article. Review.

10

A spoonful of DHAP keeps mTORC1 running on sugars.

Hoxhaj G, Locasale JW, Ben-Sahra I. Hoxhaj G, et al. Nat Metab. 2020 Sep;2(9):801-802. doi: 10.1038/s42255-020-0246-1. Nat Metab. 2020. PMID: 32719540 No abstract available.

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