Dai A - Search Results

1

Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24.

Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW. Cong Z, et al. Among authors: dai a. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2200155119. doi: 10.1073/pnas.2200155119. Epub 2022 May 13. Proc Natl Acad Sci U S A. 2022. PMID: 35561211 Free PMC article.

2

The putative signal peptide of glucagon-like peptide-1 receptor is not required for receptor synthesis but promotes receptor expression.

Ge Y, Yang D, Dai A, Zhou C, Zhu Y, Wang MW. Ge Y, et al. Among authors: dai a. Biosci Rep. 2014 Nov 21;34(6):e00152. doi: 10.1042/BSR20140120. Biosci Rep. 2014. PMID: 25330813 Free PMC article.

3

Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).

Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW. Yang D, et al. Among authors: dai a. J Biol Chem. 2016 Jun 17;291(25):12991-3004. doi: 10.1074/jbc.M116.721977. Epub 2016 Apr 8. J Biol Chem. 2016. PMID: 27059958 Free PMC article.

4

Design, synthesis, structure-activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists.

Shu S, Cai X, Li J, Feng Y, Dai A, Wang J, Yang D, Wang MW, Liu H. Shu S, et al. Among authors: dai a. Bioorg Med Chem. 2016 Jun 15;24(12):2852-63. doi: 10.1016/j.bmc.2016.04.053. Epub 2016 Apr 26. Bioorg Med Chem. 2016. PMID: 27161876

5

Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.

Zhao LH, Yin Y, Yang D, Liu B, Hou L, Wang X, Pal K, Jiang Y, Feng Y, Cai X, Dai A, Liu M, Wang MW, Melcher K, Xu HE. Zhao LH, et al. Among authors: dai a. J Biol Chem. 2016 Jul 15;291(29):15119-30. doi: 10.1074/jbc.M116.726620. Epub 2016 May 13. J Biol Chem. 2016. PMID: 27226600 Free PMC article.

6

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC. Song G, et al. Among authors: dai a. Nature. 2017 Jun 8;546(7657):312-315. doi: 10.1038/nature22378. Epub 2017 May 17. Nature. 2017. PMID: 28514449

7

Structure of the full-length glucagon class B G-protein-coupled receptor.

Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B. Zhang H, et al. Among authors: dai a. Nature. 2017 Jun 8;546(7657):259-264. doi: 10.1038/nature22363. Epub 2017 May 17. Nature. 2017. PMID: 28514451 Free PMC article.

8

Structure of the glucagon receptor in complex with a glucagon analogue.

Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B. Zhang H, et al. Among authors: dai a. Nature. 2018 Jan 3;553(7686):106-110. doi: 10.1038/nature25153. Nature. 2018. PMID: 29300013

9

Discovery of thiophene-containing biaryl amide derivatives as novel glucagon receptor antagonists.

Li J, Feng Y, Li H, Shu S, Dai A, Cai X, Wang J, Yang D, Ma D, Wang MW, Liu H. Li J, et al. Among authors: dai a. Chem Biol Drug Des. 2018 Jul;92(1):1241-1254. doi: 10.1111/cbdd.13184. Epub 2018 Apr 10. Chem Biol Drug Des. 2018. PMID: 29469980

10

A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities.

Shu S, Dai A, Wang J, Wang B, Feng Y, Li J, Cai X, Yang D, Ma D, Wang MW, Liu H. Shu S, et al. Among authors: dai a. Bioorg Med Chem. 2018 May 1;26(8):1896-1908. doi: 10.1016/j.bmc.2018.02.036. Epub 2018 Feb 22. Bioorg Med Chem. 2018. PMID: 29523469

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