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CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.
Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD. Lo M, et al. Among authors: raleigh dr. Nat Commun. 2022 May 3;13(1):2407. doi: 10.1038/s41467-022-30186-x. Nat Commun. 2022. PMID: 35504891 Free PMC article.
Hedgehog signaling drives medulloblastoma growth via CDK6.
Raleigh DR, Choksi PK, Krup AL, Mayer W, Santos N, Reiter JF. Raleigh DR, et al. J Clin Invest. 2018 Jan 2;128(1):120-124. doi: 10.1172/JCI92710. Epub 2017 Nov 20. J Clin Invest. 2018. PMID: 29202464 Free PMC article.
Cilia-Associated Oxysterols Activate Smoothened.
Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. Raleigh DR, et al. Mol Cell. 2018 Oct 18;72(2):316-327.e5. doi: 10.1016/j.molcel.2018.08.034. Mol Cell. 2018. PMID: 30340023 Free PMC article.
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.
Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR. Findakly S, et al. Among authors: raleigh dr. J Cell Biol. 2021 Jan 4;220(1):e202002026. doi: 10.1083/jcb.202002026. J Cell Biol. 2021. PMID: 33284321 Free PMC article.
NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy.
Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Bush NAO, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR. Choudhury A, et al. Among authors: raleigh dr. bioRxiv [Preprint]. 2023 Jul 11:2023.07.10.548456. doi: 10.1101/2023.07.10.548456. bioRxiv. 2023. Update in: Cancer Discov. 2024 Oct 4;14(10):1823-1837. doi: 10.1158/2159-8290.CD-23-1459 PMID: 37503127 Free PMC article. Updated. Preprint.
168 results