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Page 1
Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administration.
Nicolai L, Leunig A, Pekayvaz K, Esefeld M, Anjum A, Rath J, Riedlinger E, Ehreiser V, Mader M, Eivers L, Hoffknecht ML, Zhang Z, Kugelmann D, Rossaro D, Escaig R, Kaiser R, Polewka V, Titova A, Petzold T, Spiekermann K, Iannacone M, Thiele T, Greinacher A, Stark K, Massberg S. Nicolai L, et al. Among authors: escaig r. Blood. 2022 Aug 4;140(5):478-490. doi: 10.1182/blood.2021014712. Blood. 2022. PMID: 35486845 Free PMC article.
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
Kaiser R, Leunig A, Pekayvaz K, Popp O, Joppich M, Polewka V, Escaig R, Anjum A, Hoffknecht ML, Gold C, Brambs S, Engel A, Stockhausen S, Knottenberg V, Titova A, Haji M, Scherer C, Muenchhoff M, Hellmuth JC, Saar K, Schubert B, Hilgendorff A, Schulz C, Kääb S, Zimmer R, Hübner N, Massberg S, Mertins P, Nicolai L, Stark K. Kaiser R, et al. Among authors: escaig r. JCI Insight. 2021 Sep 22;6(18):e150862. doi: 10.1172/jci.insight.150862. JCI Insight. 2021. PMID: 34403366 Free PMC article.
Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI.
Kaiser R, Escaig R, Kranich J, Hoffknecht ML, Anjum A, Polewka V, Mader M, Hu W, Belz L, Gold C, Titova A, Lorenz M, Pekayvaz K, Kääb S, Gaertner F, Stark K, Brocker T, Massberg S, Nicolai L. Kaiser R, et al. Among authors: escaig r. Blood. 2022 Jul 14;140(2):121-139. doi: 10.1182/blood.2021014914. Blood. 2022. PMID: 35472164 Free PMC article.
Mechanosensing via a GpIIb/Src/14-3-3ζ axis critically regulates platelet migration in vascular inflammation.
Kaiser R, Anjum A, Kammerer L, Loew Q, Akhalkatsi A, Rossaro D, Escaig R, Droste Zu Senden A, Raude B, Lorenz M, Gold C, Pekayvaz K, Brocker T, Kranich J, Holch JW, Spiekermann K, Massberg S, Gaertner F, Nicolai L. Kaiser R, et al. Among authors: escaig r. Blood. 2023 Jun 15;141(24):2973-2992. doi: 10.1182/blood.2022019210. Blood. 2023. PMID: 37018659 Free PMC article.
Procoagulant platelet activation promotes venous thrombosis.
Kaiser R, Dewender R, Mulkers M, Stermann J, Rossaro D, Di Fina L, Li L, Gold C, Schmid M, Kääb L, Eivers L, Akgöl S, Yue K, Kammerer LM, Loew Q, Anjum A, Escaig R, Akhalkatsi A, Laun LS, Kranich J, Brocker T, Mueller TT, Kraechan A, Gmeiner J, Pekayvaz K, Thienel M, Massberg S, Stark K, Kilani B, Nicolai L. Kaiser R, et al. Among authors: escaig r. Blood. 2024 Oct 23:blood.2024025476. doi: 10.1182/blood.2024025476. Online ahead of print. Blood. 2024. PMID: 39440970 Free article.
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
Pekayvaz K, Losert C, Knottenberg V, Gold C, van Blokland IV, Oelen R, Groot HE, Benjamins JW, Brambs S, Kaiser R, Gottschlich A, Hoffmann GV, Eivers L, Martinez-Navarro A, Bruns N, Stiller S, Akgöl S, Yue K, Polewka V, Escaig R, Joppich M, Janjic A, Popp O, Kobold S, Petzold T, Zimmer R, Enard W, Saar K, Mertins P, Huebner N, van der Harst P, Franke LH, van der Wijst MGP, Massberg S, Heinig M, Nicolai L, Stark K. Pekayvaz K, et al. Among authors: escaig r. Nat Med. 2024 Jun;30(6):1696-1710. doi: 10.1038/s41591-024-02953-4. Epub 2024 May 21. Nat Med. 2024. PMID: 38773340 Free PMC article.
Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment.
Kaiser R, Gold C, Joppich M, Loew Q, Akhalkatsi A, Mueller TT, Offensperger F, Droste Zu Senden A, Popp O, di Fina L, Knottenberg V, Martinez-Navarro A, Eivers L, Anjum A, Escaig R, Bruns N, Briem E, Dewender R, Muraly A, Akgöl S, Ferraro B, Hoeflinger JKL, Polewka V, Khaled NB, Allgeier J, Tiedt S, Dichgans M, Engelmann B, Enard W, Mertins P, Hubner N, Weckbach L, Zimmer R, Massberg S, Stark K, Nicolai L, Pekayvaz K. Kaiser R, et al. Among authors: escaig r. Sci Adv. 2024 Mar 22;10(12):eadl1710. doi: 10.1126/sciadv.adl1710. Epub 2024 Mar 22. Sci Adv. 2024. PMID: 38517968 Free PMC article.