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Page 1
In situ identification of cellular drug targets in mammalian tissue.
Pang Z, Schafroth MA, Ogasawara D, Wang Y, Nudell V, Lal NK, Yang D, Wang K, Herbst DM, Ha J, Guijas C, Blankman JL, Cravatt BF, Ye L. Pang Z, et al. Among authors: guijas c. Cell. 2022 May 12;185(10):1793-1805.e17. doi: 10.1016/j.cell.2022.03.040. Epub 2022 Apr 27. Cell. 2022. PMID: 35483372 Free PMC article.
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.
Rinschen MM, Palygin O, El-Meanawy A, Domingo-Almenara X, Palermo A, Dissanayake LV, Golosova D, Schafroth MA, Guijas C, Demir F, Jaegers J, Gliozzi ML, Xue J, Hoehne M, Benzing T, Kok BP, Saez E, Bleich M, Himmerkus N, Weisz OA, Cravatt BF, Krüger M, Benton HP, Siuzdak G, Staruschenko A. Rinschen MM, et al. Among authors: guijas c. Nat Commun. 2022 Jul 14;13(1):4099. doi: 10.1038/s41467-022-31670-0. Nat Commun. 2022. PMID: 35835746 Free PMC article.
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.
Feldman HC, Merlini E, Guijas C, DeMeester KE, Njomen E, Kozina EM, Yokoyama M, Vinogradova E, Reardon HT, Melillo B, Schreiber SL, Loreto A, Blankman JL, Cravatt BF. Feldman HC, et al. Among authors: guijas c. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2208457119. doi: 10.1073/pnas.2208457119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994671 Free PMC article.
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux.
Spangenberg SH, Palermo A, Gazaniga NR, Martínez-Peña F, Guijas C, Chin EN, Rinschen MM, Sander PN, Webb B, Pereira LE, Jia Y, Meitz L, Siuzdak G, Lairson LL. Spangenberg SH, et al. Among authors: guijas c. Cell Chem Biol. 2023 Sep 21;30(9):1115-1134.e10. doi: 10.1016/j.chembiol.2023.06.016. Epub 2023 Jul 18. Cell Chem Biol. 2023. PMID: 37467751 Free PMC article.
XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules.
Domingo-Almenara X, Montenegro-Burke JR, Ivanisevic J, Thomas A, Sidibé J, Teav T, Guijas C, Aisporna AE, Rinehart D, Hoang L, Nordström A, Gómez-Romero M, Whiley L, Lewis MR, Nicholson JK, Benton HP, Siuzdak G. Domingo-Almenara X, et al. Among authors: guijas c. Nat Methods. 2018 Sep;15(9):681-684. doi: 10.1038/s41592-018-0110-3. Epub 2018 Aug 27. Nat Methods. 2018. PMID: 30150755 Free PMC article.
Metabolic rewiring of the hypertensive kidney.
Rinschen MM, Palygin O, Guijas C, Palermo A, Palacio-Escat N, Domingo-Almenara X, Montenegro-Burke R, Saez-Rodriguez J, Staruschenko A, Siuzdak G. Rinschen MM, et al. Among authors: guijas c. Sci Signal. 2019 Dec 10;12(611):eaax9760. doi: 10.1126/scisignal.aax9760. Sci Signal. 2019. PMID: 31822592 Free PMC article.
41 results