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Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion.
Georgiadou E, Muralidharan C, Martinez M, Chabosseau P, Akalestou E, Tomas A, Wern FYS, Stylianides T, Wretlind A, Legido-Quigley C, Jones B, Lopez-Noriega L, Xu Y, Gu G, Alsabeeh N, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Ali Y, Soleimanpour SA, Linnemann AK, Rodriguez TA, Rutter GA. Georgiadou E, et al. Diabetes. 2022 Jul 1;71(7):1472-1489. doi: 10.2337/db21-0800. Diabetes. 2022. PMID: 35472764 Free PMC article.
The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.
Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA. Georgiadou E, et al. Diabetologia. 2020 Jul;63(7):1368-1381. doi: 10.1007/s00125-020-05148-x. Epub 2020 Apr 29. Diabetologia. 2020. PMID: 32350566 Free PMC article.
The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
Carrat GR, Haythorne E, Tomas A, Haataja L, Müller A, Arvan P, Piunti A, Cheng K, Huang M, Pullen TJ, Georgiadou E, Stylianides T, Amirruddin NS, Salem V, Distaso W, Cakebread A, Heesom KJ, Lewis PA, Hodson DJ, Briant LJ, Fung ACH, Sessions RB, Alpy F, Kong APS, Benke PI, Torta F, Teo AKK, Leclerc I, Solimena M, Wigley DB, Rutter GA. Carrat GR, et al. Among authors: georgiadou e. Mol Metab. 2020 Oct;40:101015. doi: 10.1016/j.molmet.2020.101015. Epub 2020 May 13. Mol Metab. 2020. PMID: 32416313 Free PMC article.
Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo.
Salem V, Silva LD, Suba K, Georgiadou E, Neda Mousavy Gharavy S, Akhtar N, Martin-Alonso A, Gaboriau DCA, Rothery SM, Stylianides T, Carrat G, Pullen TJ, Singh SP, Hodson DJ, Leclerc I, Shapiro AMJ, Marchetti P, Briant LJB, Distaso W, Ninov N, Rutter GA. Salem V, et al. Among authors: georgiadou e. Nat Metab. 2019 Jun;1(6):615-629. doi: 10.1038/s42255-019-0075-2. Epub 2019 Jun 14. Nat Metab. 2019. PMID: 32694805
A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.
Amouyal C, Castel J, Guay C, Lacombe A, Denom J, Migrenne-Li S, Rouault C, Marquet F, Georgiadou E, Stylianides T, Luquet S, Le Stunff H, Scharfmann R, Clément K, Rutter GA, Taboureau O, Magnan C, Regazzi R, Andreelli F. Amouyal C, et al. Among authors: georgiadou e. EBioMedicine. 2020 Aug;58:102895. doi: 10.1016/j.ebiom.2020.102895. Epub 2020 Jul 30. EBioMedicine. 2020. PMID: 32739864 Free PMC article.
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.
Mousavy Gharavy SN, Owen BM, Millership SJ, Chabosseau P, Pizza G, Martinez-Sanchez A, Tasoez E, Georgiadou E, Hu M, Fine NHF, Jacobson DA, Dickerson MT, Idevall-Hagren O, Montoya A, Kramer H, Mehta Z, Withers DJ, Ninov N, Gadue PJ, Cardenas-Diaz FL, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Voz M, Rutter GA. Mousavy Gharavy SN, et al. Among authors: georgiadou e. Diabetologia. 2021 Apr;64(4):850-864. doi: 10.1007/s00125-020-05350-x. Epub 2021 Jan 25. Diabetologia. 2021. PMID: 33492421 Free PMC article.
111 results