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IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.
Das Gupta D, Paul C, Samel N, Bieringer M, Staudenraus D, Marini F, Raifer H, Menke L, Hansal L, Camara B, Roth E, Daum P, Wanzel M, Mernberger M, Nist A, Bauer UM, Helmprobst F, Buchholz M, Roth K, Bastian L, Hartmann AM, Baldus C, Ikuta K, Neubauer A, Burchert A, Jäck HM, Klein M, Bopp T, Stiewe T, Pagenstecher A, Lohoff M. Das Gupta D, et al. Among authors: mernberger m. Cell Death Differ. 2022 Nov;29(11):2163-2176. doi: 10.1038/s41418-022-01005-z. Epub 2022 Apr 22. Cell Death Differ. 2022. PMID: 35459909 Free PMC article.
Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase.
Merle N, Elmshäuser S, Strassheimer F, Wanzel M, König AM, Funk J, Neumann M, Kochhan K, Helmprobst F, Pagenstecher A, Nist A, Mernberger M, Schneider A, Braun T, Borggrefe T, Savai R, Timofeev O, Stiewe T. Merle N, et al. Among authors: mernberger m. Mol Cancer. 2022 Oct 3;21(1):191. doi: 10.1186/s12943-022-01661-2. Mol Cancer. 2022. PMID: 36192757 Free PMC article.
p53 partial loss-of-function mutations sensitize to chemotherapy.
Klimovich B, Merle N, Neumann M, Elmshäuser S, Nist A, Mernberger M, Kazdal D, Stenzinger A, Timofeev O, Stiewe T. Klimovich B, et al. Among authors: mernberger m. Oncogene. 2022 Feb;41(7):1011-1023. doi: 10.1038/s41388-021-02141-5. Epub 2021 Dec 14. Oncogene. 2022. PMID: 34907344 Free PMC article.
31 results