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Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling.
Philip NH, Dillon CP, Snyder AG, Fitzgerald P, Wynosky-Dolfi MA, Zwack EE, Hu B, Fitzgerald L, Mauldin EA, Copenhaver AM, Shin S, Wei L, Parker M, Zhang J, Oberst A, Green DR, Brodsky IE. Philip NH, et al. Among authors: brodsky ie. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7385-90. doi: 10.1073/pnas.1403252111. Epub 2014 May 5. Proc Natl Acad Sci U S A. 2014. PMID: 24799700 Free PMC article.
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES. Mandal P, et al. Among authors: brodsky ie. Immunity. 2018 Jul 17;49(1):42-55.e6. doi: 10.1016/j.immuni.2018.06.011. Immunity. 2018. PMID: 30021146 Free PMC article.
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling.
Chen KW, Demarco B, Ramos S, Heilig R, Goris M, Grayczyk JP, Assenmacher CA, Radaelli E, Joannas LD, Henao-Mejia J, Tacchini-Cottier F, Brodsky IE, Broz P. Chen KW, et al. Among authors: brodsky ie. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2101189118. doi: 10.1073/pnas.2101189118. Proc Natl Acad Sci U S A. 2021. PMID: 34260403 Free PMC article.
TLR priming licenses NAIP inflammasome activation by immunoevasive ligands.
Grayczyk JP, Egan MS, Liu L, Aunins E, Wynosky-Dolfi MA, Canna S, Minn AJ, Shin S, Brodsky IE. Grayczyk JP, et al. Among authors: brodsky ie. bioRxiv [Preprint]. 2023 May 4:2023.05.04.539437. doi: 10.1101/2023.05.04.539437. bioRxiv. 2023. PMID: 37205371 Free PMC article. Preprint.
93 results