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Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies.
Tu J, Huo Z, Yu Y, Zhu D, Xu A, Huang MF, Hu R, Wang R, Gingold JA, Chen YH, Tsai KL, Forcioli-Conti NR, Huang SXL, Webb TR, Su J, Bazer DA, Jia P, Yustein JT, Wang LL, Hung MC, Zhao Z, Huff CD, Shen J, Zhao R, Lee DF. Tu J, et al. Among authors: webb tr. Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2117857119. doi: 10.1073/pnas.2117857119. Epub 2022 Apr 11. Proc Natl Acad Sci U S A. 2022. PMID: 35412907 Free PMC article.
The spliceosome is a therapeutic vulnerability in MYC-driven cancer.
Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF. Hsu TY, et al. Among authors: webb tr. Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2. Nature. 2015. PMID: 26331541 Free PMC article.
USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.
Fraile JM, Manchado E, Lujambio A, Quesada V, Campos-Iglesias D, Webb TR, Lowe SW, López-Otín C, Freije JM. Fraile JM, et al. Among authors: webb tr. J Biol Chem. 2017 Mar 10;292(10):4164-4175. doi: 10.1074/jbc.M116.762757. Epub 2017 Feb 1. J Biol Chem. 2017. PMID: 28154181 Free PMC article.
Radiosynthesis of antitumor spliceosome modulators.
Goronga T, Boyd VA, Lagisetti C, Jeffries C, Webb TR. Goronga T, et al. Among authors: webb tr. Appl Radiat Isot. 2011 Sep;69(9):1231-4. doi: 10.1016/j.apradiso.2011.04.008. Epub 2011 Apr 16. Appl Radiat Isot. 2011. PMID: 21531567 Free PMC article.
Optimization of antitumor modulators of pre-mRNA splicing.
Lagisetti C, Palacios G, Goronga T, Freeman B, Caufield W, Webb TR. Lagisetti C, et al. Among authors: webb tr. J Med Chem. 2013 Dec 27;56(24):10033-44. doi: 10.1021/jm401370h. Epub 2013 Dec 11. J Med Chem. 2013. PMID: 24325474 Free PMC article.
159 results