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USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy.
Xiong W, Gao X, Zhang T, Jiang B, Hu MM, Bu X, Gao Y, Zhang LZ, Xiao BL, He C, Sun Y, Li H, Shi J, Xiao X, Xiang B, Xie C, Chen G, Zhang H, Wei W, Freeman GJ, Shu HB, Wang H, Zhang J. Xiong W, et al. Among authors: gao x, gao y. Nat Commun. 2022 Mar 31;13(1):1700. doi: 10.1038/s41467-022-29401-6. Nat Commun. 2022. PMID: 35361799 Free PMC article.
Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis.
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker BL, Yang R, Feltcher C, Peng K, Feng C, Chen H, Lee RX, Kerestes H, Niu J, Kumar S, Xu W, Zhang J, Wei Z, Martin JS, Liu X, Mills G, Lu Y, Guo W, Sun L, Zhang L, Weeraratna A, Herlyn M, Wei W, Lee FS, Xu X. Liu S, et al. Among authors: gao y. Nat Commun. 2018 Dec 21;9(1):5426. doi: 10.1038/s41467-018-07126-9. Nat Commun. 2018. PMID: 30575721 Free PMC article.
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy.
Gao Y, Nihira NT, Bu X, Chu C, Zhang J, Kolodziejczyk A, Fan Y, Chan NT, Ma L, Liu J, Wang D, Dai X, Liu H, Ono M, Nakanishi A, Inuzuka H, North BJ, Huang YH, Sharma S, Geng Y, Xu W, Liu XS, Li L, Miki Y, Sicinski P, Freeman GJ, Wei W. Gao Y, et al. Nat Cell Biol. 2020 Sep;22(9):1064-1075. doi: 10.1038/s41556-020-0562-4. Epub 2020 Aug 24. Nat Cell Biol. 2020. PMID: 32839551 Free PMC article.
Acetylation-dependent regulation of BRAF oncogenic function.
Dai X, Zhang X, Yin Q, Hu J, Guo J, Gao Y, Snell AH, Inuzuka H, Wan L, Wei W. Dai X, et al. Among authors: gao y. Cell Rep. 2022 Jan 18;38(3):110250. doi: 10.1016/j.celrep.2021.110250. Cell Rep. 2022. PMID: 35045286 Free PMC article.
UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity.
He C, Xing X, Chen HY, Gao M, Shi J, Xiang B, Xiao X, Sun Y, Yu H, Xu G, Yao Y, Xie Z, Xing Y, Budiarto BR, Chen SY, Gao Y, Lee YR, Zhang J. He C, et al. Among authors: gao y, gao m. Mol Cell. 2024 Mar 21;84(6):1120-1138.e8. doi: 10.1016/j.molcel.2024.01.024. Epub 2024 Feb 19. Mol Cell. 2024. PMID: 38377992
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