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The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride does not improve joint damage in an experimental model of knee osteoarthritis in rabbits.
Roman-Blas JA, Mediero A, Tardío L, Portal-Nuñez S, Gratal P, Herrero-Beaumont G, Largo R. Roman-Blas JA, et al. Among authors: mediero a. Eur J Pharmacol. 2017 Jan 5;794:8-14. doi: 10.1016/j.ejphar.2016.11.015. Epub 2016 Nov 12. Eur J Pharmacol. 2017. PMID: 27845067
Unexpected Bone Formation Produced by RANKL Blockade.
Portal-Núñez S, Mediero A, Esbrit P, Sánchez-Pernaute O, Largo R, Herrero-Beaumont G. Portal-Núñez S, et al. Among authors: mediero a. Trends Endocrinol Metab. 2017 Oct;28(10):695-704. doi: 10.1016/j.tem.2017.06.003. Epub 2017 Jul 19. Trends Endocrinol Metab. 2017. PMID: 28733136 Review.
Adenosine A2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis.
Mediero A, Wilder T, Shah L, Cronstein BN. Mediero A, et al. FASEB J. 2018 Jul;32(7):3487-3501. doi: 10.1096/fj.201700217R. Epub 2018 Feb 2. FASEB J. 2018. PMID: 29394106 Free PMC article.
Sema4D increased Ras homolog gene family, member A phosphorylation and focal adhesion kinase activation in osteoclast precursors, and CGS21680 abrogated these effects. In summary, A2AR activation diminishes secretion of Sema4D by osteoclasts, inhibits Sema4D-mediated osteo …
Sema4D increased Ras homolog gene family, member A phosphorylation and focal adhesion kinase activation in osteoclast precursors, and …
Chondrocyte enlargement is a marker of osteoarthritis severity.
Gratal P, Mediero A, Sánchez-Pernaute O, Prieto-Potin I, Lamuedra A, Herrero-Beaumont G, Largo R. Gratal P, et al. Among authors: mediero a. Osteoarthritis Cartilage. 2019 Aug;27(8):1229-1234. doi: 10.1016/j.joca.2019.04.013. Epub 2019 Apr 30. Osteoarthritis Cartilage. 2019. PMID: 31051241 Free article.
Treating osteoporotic osteoarthritis, or the art of cutting a balding man's hair.
Herrero-Beaumont G, Roman-Blas JA, Mediero A, Sánchez-Pernaute O, Largo R. Herrero-Beaumont G, et al. Among authors: mediero a. Osteoarthritis Cartilage. 2020 Mar;28(3):239-241. doi: 10.1016/j.joca.2019.10.015. Epub 2019 Dec 18. Osteoarthritis Cartilage. 2020. PMID: 31863830 Free article. No abstract available.
Purinergic System Signaling in Metainflammation-Associated Osteoarthritis.
Gratal P, Lamuedra A, Medina JP, Bermejo-Álvarez I, Largo R, Herrero-Beaumont G, Mediero A. Gratal P, et al. Among authors: mediero a. Front Med (Lausanne). 2020 Aug 28;7:506. doi: 10.3389/fmed.2020.00506. eCollection 2020. Front Med (Lausanne). 2020. PMID: 32984382 Free PMC article. Review.
73 results