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Lysosomal inhibition sensitizes TMEM16A-expressing cancer cells to chemotherapy.
Vyas A, Gomez-Casal R, Cruz-Rangel S, Villanueva H, Sikora AG, Rajagopalan P, Basu D, Pacheco J, Hammond GRV, Kiselyov K, Duvvuri U. Vyas A, et al. Among authors: cruz rangel s. Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2100670119. doi: 10.1073/pnas.2100670119. Epub 2022 Mar 14. Proc Natl Acad Sci U S A. 2022. PMID: 35286200 Free PMC article.
Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1).
De Jesús-Pérez JJ, Cruz-Rangel S, Espino-Saldaña ÁE, Martínez-Torres A, Qu Z, Hartzell HC, Corral-Fernandez NE, Pérez-Cornejo P, Arreola J. De Jesús-Pérez JJ, et al. Among authors: cruz rangel s. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Mar;1863(3):299-312. doi: 10.1016/j.bbalip.2017.12.009. Epub 2017 Dec 22. Biochim Biophys Acta Mol Cell Biol Lipids. 2018. PMID: 29277655 Free PMC article.
Similar effects of all WNK3 variants on SLC12 cotransporters.
Cruz-Rangel S, Melo Z, Vázquez N, Meade P, Bobadilla NA, Pasantes-Morales H, Gamba G, Mercado A. Cruz-Rangel S, et al. Am J Physiol Cell Physiol. 2011 Sep;301(3):C601-8. doi: 10.1152/ajpcell.00070.2011. Epub 2011 May 25. Am J Physiol Cell Physiol. 2011. PMID: 21613606 Free article.
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