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A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.
Ye L, Park JJ, Peng L, Yang Q, Chow RD, Dong MB, Lam SZ, Guo J, Tang E, Zhang Y, Wang G, Dai X, Du Y, Kim HR, Cao H, Errami Y, Clark P, Bersenev A, Montgomery RR, Chen S. Ye L, et al. Among authors: lam sz. Cell Metab. 2022 Apr 5;34(4):595-614.e14. doi: 10.1016/j.cmet.2022.02.009. Epub 2022 Mar 10. Cell Metab. 2022. PMID: 35276062 Free PMC article.
Genome Engineering for Next-Generation Cellular Immunotherapies.
Park JJ, Lee KAV, Lam SZ, Tang K, Chen S. Park JJ, et al. Among authors: lam sz. Biochemistry. 2023 Dec 19;62(24):3455-3464. doi: 10.1021/acs.biochem.2c00340. Epub 2022 Aug 5. Biochemistry. 2023. PMID: 35930700 Free PMC article. Review.
Massively parallel knock-in engineering of human T cells.
Dai X, Park JJ, Du Y, Na Z, Lam SZ, Chow RD, Renauer PA, Gu J, Xin S, Chu Z, Liao C, Clark P, Zhao H, Slavoff S, Chen S. Dai X, et al. Among authors: lam sz. Nat Biotechnol. 2023 Sep;41(9):1239-1255. doi: 10.1038/s41587-022-01639-x. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702900 Free PMC article.
Perturbomics of tumor-infiltrating NK cells.
Peng L, Renauer PA, Ye L, Yang L, Park JJ, Chow RD, Zhang Y, Lin Q, Bai M, Sanchez A, Zhang Y, Lam SZ, Chen S. Peng L, et al. Among authors: lam sz. bioRxiv [Preprint]. 2023 Mar 15:2023.03.14.532653. doi: 10.1101/2023.03.14.532653. bioRxiv. 2023. PMID: 36993337 Free PMC article. Preprint.
11 results