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Page 1
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.
Pataskar A, Champagne J, Nagel R, Kenski J, Laos M, Michaux J, Pak HS, Bleijerveld OB, Mordente K, Navarro JM, Blommaert N, Nielsen MM, Lovecchio D, Stone E, Georgiou G, de Gooijer MC, van Tellingen O, Altelaar M, Joosten RP, Perrakis A, Olweus J, Bassani-Sternberg M, Peeper DS, Agami R. Pataskar A, et al. Among authors: perrakis a. Nature. 2022 Mar;603(7902):721-727. doi: 10.1038/s41586-022-04499-2. Epub 2022 Mar 9. Nature. 2022. PMID: 35264796 Free PMC article.
RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.
Kedde M, Strasser MJ, Boldajipour B, Oude Vrielink JA, Slanchev K, le Sage C, Nagel R, Voorhoeve PM, van Duijse J, Ørom UA, Lund AH, Perrakis A, Raz E, Agami R. Kedde M, et al. Among authors: perrakis a. Cell. 2007 Dec 28;131(7):1273-86. doi: 10.1016/j.cell.2007.11.034. Cell. 2007. PMID: 18155131 Free article.
Automatic rebuilding and optimization of crystallographic structures in the Protein Data Bank.
Joosten RP, Joosten K, Cohen SX, Vriend G, Perrakis A. Joosten RP, et al. Among authors: perrakis a. Bioinformatics. 2011 Dec 15;27(24):3392-8. doi: 10.1093/bioinformatics/btr590. Epub 2011 Oct 27. Bioinformatics. 2011. PMID: 22034521 Free PMC article.
MOTIVATION: Macromolecular crystal structures in the Protein Data Bank (PDB) are a key source of structural insight into biological processes. These structures, some >30 years old, were constructed with methods of their era. ...CONTACT: r.joosten@nki.nl; a.per …
MOTIVATION: Macromolecular crystal structures in the Protein Data Bank (PDB) are a key source of structural insight into biological p …
PDB_REDO: constructive validation, more than just looking for errors.
Joosten RP, Joosten K, Murshudov GN, Perrakis A. Joosten RP, et al. Among authors: perrakis a. Acta Crystallogr D Biol Crystallogr. 2012 Apr;68(Pt 4):484-96. doi: 10.1107/S0907444911054515. Epub 2012 Mar 16. Acta Crystallogr D Biol Crystallogr. 2012. PMID: 22505269 Free PMC article.
Timely deposition of macromolecular structures is necessary for peer review.
Joosten RP, Soueidan H, Wessels LF, Perrakis A. Joosten RP, et al. Among authors: perrakis a. Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2293-5. doi: 10.1107/S0907444913024621. Epub 2013 Nov 19. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 24311569 Free PMC article.
The first step of peptide selection in antigen presentation by MHC class I molecules.
Garstka MA, Fish A, Celie PH, Joosten RP, Janssen GM, Berlin I, Hoppes R, Stadnik M, Janssen L, Ovaa H, van Veelen PA, Perrakis A, Neefjes J. Garstka MA, et al. Among authors: perrakis a. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1505-10. doi: 10.1073/pnas.1416543112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605945 Free PMC article.
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.
Keune WJ, Hausmann J, Bolier R, Tolenaars D, Kremer A, Heidebrecht T, Joosten RP, Sunkara M, Morris AJ, Matas-Rico E, Moolenaar WH, Oude Elferink RP, Perrakis A. Keune WJ, et al. Among authors: perrakis a. Nat Commun. 2016 Apr 14;7:11248. doi: 10.1038/ncomms11248. Nat Commun. 2016. PMID: 27075612 Free PMC article.
Data Mining of Macromolecular Structures.
van Beusekom B, Perrakis A, Joosten RP. van Beusekom B, et al. Among authors: perrakis a. Methods Mol Biol. 2016;1415:107-38. doi: 10.1007/978-1-4939-3572-7_6. Methods Mol Biol. 2016. PMID: 27115630
247 results