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In vivo overexpression of frataxin causes toxicity mediated by iron-sulfur cluster deficiency.
Huichalaf C, Perfitt TL, Kuperman A, Gooch R, Kovi RC, Brenneman KA, Chen X, Hirenallur-Shanthappa D, Ma T, Assaf BT, Pardo I, Franks T, Monarski L, Cheng TW, Le K, Su C, Somanathan S, Whiteley LO, Bulawa C, Pregel MJ, Martelli A. Huichalaf C, et al. Among authors: pardo i. Mol Ther Methods Clin Dev. 2022 Feb 7;24:367-378. doi: 10.1016/j.omtm.2022.02.002. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2022. PMID: 35252470 Free PMC article.
Biodistribution and Tolerability of AAV-PHP.B-CBh-SMN1 in Wistar Han Rats and Cynomolgus Macaques Reveal Different Toxicologic Profiles.
Palazzi X, Pardo ID, Sirivelu MP, Newman L, Kumpf SW, Qian J, Franks T, Lopes S, Liu J, Monarski L, Casinghino S, Ritenour C, Ritenour H, Dubois C, Olson J, Graves J, Alexander KE, Coskran T, Lanz TA, Brady J, McCarty D, Suryanarayan S, Whiteley LO. Palazzi X, et al. Hum Gene Ther. 2022 Feb;33(3-4):175-187. doi: 10.1089/hum.2021.116. Hum Gene Ther. 2022. PMID: 34931542 Free PMC article.
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studies.
Bennet BM, Pardo ID, Assaf BT, Buza E, Cramer S, Crawford LK, Engelhardt JA, Grubor B, Morrison JP, Osborne TS, Sharma AK, Bolon B. Bennet BM, et al. Toxicol Pathol. 2023 Jun;51(4):176-204. doi: 10.1177/01926233231179707. Epub 2023 Jul 25. Toxicol Pathol. 2023. PMID: 37489508
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog.
Woicke J, Al-Haddawi MM, Bienvenu JG, Caverly Rae JM, Chanut FJ, Colman K, Cullen JM, Davis W, Fukuda R, Huisinga M, Walker UJ, Kai K, Kovi RC, Macri NP, Marxfeld HA, Nikula KJ, Pardo ID, Rosol TJ, Sharma AK, Singh BP, Tamura K, Thibodeau MS, Vezzali E, Vidal JD, Meseck EK. Woicke J, et al. Toxicol Pathol. 2021 Jan;49(1):5-109. doi: 10.1177/0192623320968181. Toxicol Pathol. 2021. PMID: 33393871
Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.
Imam SZ, He Z, Cuevas E, Rosas-Hernandez H, Lantz SM, Sarkar S, Raymick J, Robinson B, Hanig JP, Herr D, MacMillan D, Smith A, Liachenko S, Ferguson S, O'Callaghan J, Miller D, Somps C, Pardo ID, Slikker W Jr, B Pierson J, Roberts R, Gong B, Tong W, Aschner M, J Kallman M, Calligaro D, Paule MG. Imam SZ, et al. Exp Biol Med (Maywood). 2018 Feb;243(3):228-236. doi: 10.1177/1535370217739859. Epub 2017 Nov 6. Exp Biol Med (Maywood). 2018. PMID: 29105512 Free PMC article.
Animal models for neural diseases.
Jay GW, Demattos RB, Weinstein EJ, Philbert MA, Pardo ID, Brown TP. Jay GW, et al. Toxicol Pathol. 2011 Jan;39(1):167-9. doi: 10.1177/0192623310389478. Epub 2010 Nov 30. Toxicol Pathol. 2011. PMID: 21119053 Free PMC article.
174 results