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Page 1
Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele.
Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group. Middleton PG, et al. N Engl J Med. 2019 Nov 7;381(19):1809-1819. doi: 10.1056/NEJMoa1908639. Epub 2019 Oct 31. N Engl J Med. 2019. PMID: 31697873 Free PMC article. Clinical Trial.
Safety and efficacy of vanzacaftor-tezacaftor-deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials.
Uluer AZ, MacGregor G, Azevedo P, Indihar V, Keating C, Mall MA, McKone EF, Ramsey BW, Rowe SM, Rubenstein RC, Taylor-Cousar JL, Tullis E, Yonker LM, Chu C, Lam AP, Nair N, Sosnay PR, Tian S, Van Goor F, Viswanathan L, Waltz D, Wang LT, Xi Y, Billings J, Horsley A; VX18-121-101; VX18-561-101 Study Groups. Uluer AZ, et al. Lancet Respir Med. 2023 Jun;11(6):550-562. doi: 10.1016/S2213-2600(22)00504-5. Epub 2023 Feb 23. Lancet Respir Med. 2023. PMID: 36842446 Free article. Clinical Trial.
ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure.
Schulz-Kuhnt A, Greif V, Hildner K, Knipfer L, Döbrönti M, Zirlik S, Fuchs F, Atreya R, Zundler S, López-Posadas R, Neufert C, Ramming A, Kiefer A, Grüneboom A, Strasser E, Wirtz S, Neurath MF, Atreya I. Schulz-Kuhnt A, et al. Among authors: kiefer a. Front Immunol. 2020 May 7;11:691. doi: 10.3389/fimmu.2020.00691. eCollection 2020. Front Immunol. 2020. PMID: 32457736 Free PMC article.
Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Targeted deletion of Interleukin-3 results in asthma exacerbations.
Kölle J, Zimmermann T, Kiefer A, Rieker RJ, Xepapadaki P, Zundler S, Papadopoulos NG, Finotto S. Kölle J, et al. Among authors: kiefer a. iScience. 2022 May 23;25(6):104440. doi: 10.1016/j.isci.2022.104440. eCollection 2022 Jun 17. iScience. 2022. PMID: 35707726 Free PMC article.
Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).
Koch S, Knipfer L, Kölle J, Mirzakhani H, Graser A, Zimmermann T, Kiefer A, Melichar VO, Rascher W, Papadopoulos NG, Rieker RJ, Raby BA, Weiss ST, Wirtz S, Finotto S. Koch S, et al. Among authors: kiefer a. Sci Rep. 2019 Oct 30;9(1):15695. doi: 10.1038/s41598-019-51690-z. Sci Rep. 2019. PMID: 31666531 Free PMC article.
Contribution of repeated infections in asthma persistence from preschool to school age: Design and characteristics of the PreDicta cohort.
Xepapadaki P, Bachert C, Finotto S, Jartti T, Konstantinou GN, Kiefer A, Kowalski M, Lewandowska-Polak A, Lukkarinen H, Roumpedaki E, Sobanska A, Sintobin I, Vuorinen T, Zhang N, Zimmermann T, Papadopoulos NG. Xepapadaki P, et al. Among authors: kiefer a. Pediatr Allergy Immunol. 2018 Jun;29(4):383-393. doi: 10.1111/pai.12881. Epub 2018 Apr 10. Pediatr Allergy Immunol. 2018. PMID: 29512854
Role of TGF-β in anti-rhinovirus immune responses in asthmatic patients.
Bielor C, Sopel N, Maier A, Blau A, Sharma H, Vuorinen T, Kroß B, Mittler S, Graser A, Mousset S, Melichar VO, Kiefer A, Zimmermann T, Springel R, Holzinger C, Trump S, Taka S, Papadopoulos NG, Weiss ST, Finotto S. Bielor C, et al. Among authors: kiefer a. J Allergy Clin Immunol. 2017 Jul;140(1):283-286.e10. doi: 10.1016/j.jaci.2016.10.049. Epub 2017 Jan 27. J Allergy Clin Immunol. 2017. PMID: 28139316 Free PMC article. No abstract available.
265 results