Chen J - Search Results

1

Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviates Tripterygium Glycoside Tablet-Induced Acute Liver Injury by Regulating the Activities of CYP and the Metabolism of Phosphoglycerides.

Shi Q, Wang Q, Chen J, Xia F, Qiu C, Li M, Zhao M, Zhang Q, Luo P, Lu T, Zhang Y, Xu L, He X, Zhong T, Lin N, Guo Q. Shi Q, et al. Among authors: chen j. Front Pharmacol. 2022 Feb 14;12:822154. doi: 10.3389/fphar.2021.822154. eCollection 2021. Front Pharmacol. 2022. PMID: 35237151 Free PMC article.

2

Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.

Zhang Q, Luo P, Chen J, Yang C, Xia F, Zhang J, Tang H, Liu D, Gu L, Shi Q, He X, Yang T, Wang J. Zhang Q, et al. Among authors: chen j. Int J Biol Sci. 2022 Feb 21;18(5):2003-2017. doi: 10.7150/ijbs.69618. eCollection 2022. Int J Biol Sci. 2022. PMID: 35342337 Free PMC article.

3

Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect.

Luo P, Zhang Q, Zhong TY, Chen JY, Zhang JZ, Tian Y, Zheng LH, Yang F, Dai LY, Zou C, Li ZJ, Liu JH, Wang JG. Luo P, et al. Mil Med Res. 2022 May 20;9(1):22. doi: 10.1186/s40779-022-00381-4. Mil Med Res. 2022. PMID: 35596191 Free PMC article.

4

Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1.

Luo P, Liu D, Zhang Q, Yang F, Wong YK, Xia F, Zhang J, Chen J, Tian Y, Yang C, Dai L, Shen HM, Wang J. Luo P, et al. Among authors: chen j. Acta Pharm Sin B. 2022 May;12(5):2300-2314. doi: 10.1016/j.apsb.2021.12.007. Epub 2021 Dec 18. Acta Pharm Sin B. 2022. PMID: 35646542 Free PMC article.

5

Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA.

Gao P, Liu YQ, Xiao W, Xia F, Chen JY, Gu LW, Yang F, Zheng LH, Zhang JZ, Zhang Q, Li ZJ, Meng YQ, Zhu YP, Tang H, Shi QL, Guo QY, Zhang Y, Xu CC, Dai LY, Wang JG. Gao P, et al. Mil Med Res. 2022 Jun 14;9(1):30. doi: 10.1186/s40779-022-00390-3. Mil Med Res. 2022. PMID: 35698214 Free PMC article.

6

Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy.

Chen J, Luo P, Wang C, Yang C, Bai Y, He X, Zhang Q, Zhang J, Yang J, Wang S, Wang J. Chen J, et al. JCI Insight. 2022 Aug 22;7(16):e157360. doi: 10.1172/jci.insight.157360. JCI Insight. 2022. PMID: 35852860 Free PMC article.

7

Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis.

Zhang Q, Luo P, Xia F, Tang H, Chen J, Zhang J, Liu D, Zhu Y, Liu Y, Gu L, Zheng L, Li Z, Yang F, Dai L, Liao F, Xu C, Wang J. Zhang Q, et al. Among authors: chen j. Cell Chem Biol. 2022 Aug 18;29(8):1248-1259.e6. doi: 10.1016/j.chembiol.2022.06.011. Epub 2022 Jul 19. Cell Chem Biol. 2022. PMID: 35858615 Free article.

8

18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs.

Zhang Q, Luo P, Zheng L, Chen J, Zhang J, Tang H, Liu D, He X, Shi Q, Gu L, Li J, Guo Q, Yang C, Wong YK, Xia F, Wang J. Zhang Q, et al. Among authors: chen j. J Pharm Anal. 2022 Aug;12(4):570-582. doi: 10.1016/j.jpha.2022.06.001. Epub 2022 Jun 8. J Pharm Anal. 2022. PMID: 36105163 Free PMC article.

9

Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics.

Luo P, Chen J, Zhang Q, Xia F, Wang C, Bai Y, Tang H, Liu D, Gu L, Du Q, Xiao W, Yang C, Wang J. Luo P, et al. Among authors: chen j. Precis Clin Med. 2022 Sep 22;5(4):pbac023. doi: 10.1093/pcmedi/pbac023. eCollection 2022 Dec. Precis Clin Med. 2022. PMID: 36349141 Free PMC article.

10

Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells.

Zhang Y, Zhang Q, Chu Z, Chen L, Chen J, Yang Y, Tang H, Cheng G, Ma A, Zhang Y, Wang C, Gao P, Xia F, Guo Q, Shi Q, Han G, Wang J, Zhu Y. Zhang Y, et al. Among authors: chen j, chen l. Chem Commun (Camb). 2022 Nov 29;58(95):13250-13253. doi: 10.1039/d2cc05278d. Chem Commun (Camb). 2022. PMID: 36367053

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