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Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis.
Sáenz de Urturi D, Buqué X, Porteiro B, Folgueira C, Mora A, Delgado TC, Prieto-Fernández E, Olaizola P, Gómez-Santos B, Apodaka-Biguri M, González-Romero F, Nieva-Zuluaga A, Ruiz de Gauna M, Goikoetxea-Usandizaga N, García-Rodríguez JL, Gutierrez de Juan V, Aurrekoetxea I, Montalvo-Romeral V, Novoa EM, Martín-Guerrero I, Varela-Rey M, Bhanot S, Lee R, Banales JM, Syn WK, Sabio G, Martínez-Chantar ML, Nogueiras R, Aspichueta P. Sáenz de Urturi D, et al. Nat Commun. 2022 Mar 1;13(1):1096. doi: 10.1038/s41467-022-28749-z. Nat Commun. 2022. PMID: 35232994 Free PMC article.
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.
Martínez-Chantar ML, Vázquez-Chantada M, Garnacho M, Latasa MU, Varela-Rey M, Dotor J, Santamaria M, Martínez-Cruz LA, Parada LA, Lu SC, Mato JM. Martínez-Chantar ML, et al. Gastroenterology. 2006 Jul;131(1):223-32. doi: 10.1053/j.gastro.2006.04.019. Gastroenterology. 2006. PMID: 16831604
S-adenosylmethionine and proliferation: new pathways, new targets.
Martínez-López N, Varela-Rey M, Ariz U, Embade N, Vazquez-Chantada M, Fernandez-Ramos D, Gomez-Santos L, Lu SC, Mato JM, Martinez-Chantar ML. Martínez-López N, et al. Biochem Soc Trans. 2008 Oct;36(Pt 5):848-52. doi: 10.1042/BST0360848. Biochem Soc Trans. 2008. PMID: 18793149
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Martínez-López N, Varela-Rey M, Fernández-Ramos D, Woodhoo A, Vázquez-Chantada M, Embade N, Espinosa-Hevia L, Bustamante FJ, Parada LA, Rodriguez MS, Lu SC, Mato JM, Martínez-Chantar ML. Martínez-López N, et al. Hepatology. 2010 Nov;52(5):1621-31. doi: 10.1002/hep.23860. Hepatology. 2010. PMID: 20815019 Free PMC article.
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.
Embade N, Fernández-Ramos D, Varela-Rey M, Beraza N, Sini M, Gutiérrez de Juan V, Woodhoo A, Martínez-López N, Rodríguez-Iruretagoyena B, Bustamante FJ, de la Hoz AB, Carracedo A, Xirodimas DP, Rodríguez MS, Lu SC, Mato JM, Martínez-Chantar ML. Embade N, et al. Hepatology. 2012 Apr;55(4):1237-48. doi: 10.1002/hep.24795. Epub 2012 Mar 1. Hepatology. 2012. PMID: 22095636 Free PMC article.
Human antigen R contributes to hepatic stellate cell activation and liver fibrosis.
Woodhoo A, Iruarrizaga-Lejarreta M, Beraza N, García-Rodríguez JL, Embade N, Fernández-Ramos D, Martínez-López N, Gutiérrez-De Juan V, Arteta B, Caballeria J, Lu SC, Mato JM, Varela-Rey M, Martínez-Chantar ML. Woodhoo A, et al. Hepatology. 2012 Nov;56(5):1870-82. doi: 10.1002/hep.25828. Epub 2012 Oct 9. Hepatology. 2012. PMID: 22576182 Free PMC article.
223 results