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USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation.
Zheng Q, Song B, Li G, Cai F, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang XF, Luo H, Zhang X, Zhang H, Zeng Z, Huang TY, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H, Song W, Wang X. Zheng Q, et al. Among authors: jiang l. J Clin Invest. 2022 Mar 1;132(5):e152170. doi: 10.1172/JCI152170. J Clin Invest. 2022. PMID: 35229730 Free PMC article.
SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.
Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H. Huang TY, et al. J Exp Med. 2017 Dec 4;214(12):3669-3685. doi: 10.1084/jem.20171413. Epub 2017 Nov 7. J Exp Med. 2017. PMID: 29114064 Free PMC article.
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, Xu H. Zhao Y, et al. Neuron. 2018 Mar 7;97(5):1023-1031.e7. doi: 10.1016/j.neuron.2018.01.031. Neuron. 2018. PMID: 29518356 Free PMC article.
Intracellular trafficking of TREM2 is regulated by presenilin 1.
Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q, Xu H. Zhao Y, et al. Exp Mol Med. 2017 Dec 1;49(12):e405. doi: 10.1038/emm.2017.200. Exp Mol Med. 2017. PMID: 29611543 Free PMC article.
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