Wu Y - Search Results

1

Discovery and optimization of betulinic acid derivatives as novel potent CD73 inhibitors.

Zhang Y, Ye S, Wang Y, Wang C, Zhu Y, Wu Y, Zhang Y, Zhang H, Miao Z. Zhang Y, et al. Among authors: wu y. Bioorg Med Chem. 2022 Apr 1;59:116672. doi: 10.1016/j.bmc.2022.116672. Epub 2022 Feb 16. Bioorg Med Chem. 2022. PMID: 35217359

2

Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction.

Zhuang C, Miao Z, Zhu L, Dong G, Guo Z, Wang S, Zhang Y, Wu Y, Yao J, Sheng C, Zhang W. Zhuang C, et al. Among authors: wu y. J Med Chem. 2012 Nov 26;55(22):9630-42. doi: 10.1021/jm300969t. Epub 2012 Oct 19. J Med Chem. 2012. PMID: 23046248

3

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Miao Z, Zhu L, Dong G, Zhuang C, Wu Y, Wang S, Guo Z, Liu Y, Wu S, Zhu S, Fang K, Yao J, Li J, Sheng C, Zhang W. Miao Z, et al. Among authors: wu y, wu s. J Med Chem. 2013 Oct 24;56(20):7902-10. doi: 10.1021/jm400906z. Epub 2013 Oct 9. J Med Chem. 2013. PMID: 24069881

4

Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway.

Zhuang C, Miao Z, Wu Y, Guo Z, Li J, Yao J, Xing C, Sheng C, Zhang W. Zhuang C, et al. Among authors: wu y. J Med Chem. 2014 Feb 13;57(3):567-77. doi: 10.1021/jm401800k. Epub 2014 Jan 24. J Med Chem. 2014. PMID: 24428757

5

Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy.

Li J, Wu Y, Guo Z, Zhuang C, Yao J, Dong G, Yu Z, Min X, Wang S, Liu Y, Wu S, Zhu S, Sheng C, Miao Z, Zhang W. Li J, et al. Among authors: wu y, wu s. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2648-50. doi: 10.1016/j.bmcl.2014.04.063. Epub 2014 Apr 26. Bioorg Med Chem Lett. 2014. PMID: 24813735

6

Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents.

Wu Y, Min X, Zhuang C, Li J, Yu Z, Dong G, Yao J, Wang S, Liu Y, Wu S, Zhu S, Sheng C, Wei Y, Zhang H, Zhang W, Miao Z. Wu Y, et al. Among authors: wu s. Eur J Med Chem. 2014 Jul 23;82:545-51. doi: 10.1016/j.ejmech.2014.05.070. Epub 2014 Jun 2. Eur J Med Chem. 2014. PMID: 24937186

7

Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors.

Yu Z, Zhuang C, Wu Y, Guo Z, Li J, Dong G, Yao J, Sheng C, Miao Z, Zhang W. Yu Z, et al. Among authors: wu y. Int J Mol Sci. 2014 Sep 5;15(9):15741-53. doi: 10.3390/ijms150915741. Int J Mol Sci. 2014. PMID: 25198897 Free PMC article.

8

A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways.

Zhuang C, Sheng C, Shin WS, Wu Y, Li J, Yao J, Dong G, Zhang W, Sham YY, Miao Z, Zhang W. Zhuang C, et al. Among authors: wu y. Oncotarget. 2014 Nov 15;5(21):10830-9. doi: 10.18632/oncotarget.2521. Oncotarget. 2014. PMID: 25350970 Free PMC article.

9

Discovery of 7-Methyl-10-Hydroxyhomocamptothecins with 1,2,3-Triazole Moiety as Potent Topoisomerase I Inhibitors.

Xu X, Wu Y, Liu W, Sheng C, Yao J, Dong G, Fang K, Li J, Yu Z, Min X, Zhang H, Miao Z, Zhang W. Xu X, et al. Among authors: wu y. Chem Biol Drug Des. 2016 Sep;88(3):398-403. doi: 10.1111/cbdd.12767. Epub 2016 May 5. Chem Biol Drug Des. 2016. PMID: 27062430

10

Novel non-trimethoxylphenyl piperlongumine derivatives selectively kill cancer cells.

Zhang Y, Ma H, Wu Y, Wu Z, Yao Z, Zhang W, Zhuang C, Miao Z. Zhang Y, et al. Among authors: wu y, wu z. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2308-2312. doi: 10.1016/j.bmcl.2017.04.035. Epub 2017 Apr 13. Bioorg Med Chem Lett. 2017. PMID: 28434764

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