Wells JA - Search Results

1

Switchable assembly and function of antibody complexes in vivo using a small molecule.

Martinko AJ, Simonds EF, Prasad S, Ponce A, Bracken CJ, Wei J, Wang YH, Chow TL, Huang Z, Evans MJ, Wells JA, Hill ZB. Martinko AJ, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2117402119. doi: 10.1073/pnas.2117402119. Proc Natl Acad Sci U S A. 2022. PMID: 35210365 Free PMC article.

2

Two-state selection of conformation-specific antibodies.

Gao J, Sidhu SS, Wells JA. Gao J, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3071-6. doi: 10.1073/pnas.0812952106. Epub 2009 Feb 10. Proc Natl Acad Sci U S A. 2009. PMID: 19208804 Free PMC article.

3

Turning a protein kinase on or off from a single allosteric site via disulfide trapping.

Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA. Sadowsky JD, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6056-61. doi: 10.1073/pnas.1102376108. Epub 2011 Mar 23. Proc Natl Acad Sci U S A. 2011. PMID: 21430264 Free PMC article.

4

Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation.

Zorn JA, Wille H, Wolan DW, Wells JA. Zorn JA, et al. Among authors: wells ja. J Am Chem Soc. 2011 Dec 14;133(49):19630-3. doi: 10.1021/ja208350u. Epub 2011 Nov 17. J Am Chem Soc. 2011. PMID: 22066605 Free PMC article.

5

Global kinetic analysis of proteolysis via quantitative targeted proteomics.

Agard NJ, Mahrus S, Trinidad JC, Lynn A, Burlingame AL, Wells JA. Agard NJ, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1913-8. doi: 10.1073/pnas.1117158109. Epub 2012 Jan 23. Proc Natl Acad Sci U S A. 2012. PMID: 22308409 Free PMC article.

6

Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis.

Shimbo K, Hsu GW, Nguyen H, Mahrus S, Trinidad JC, Burlingame AL, Wells JA. Shimbo K, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12432-7. doi: 10.1073/pnas.1208616109. Epub 2012 Jul 16. Proc Natl Acad Sci U S A. 2012. PMID: 22802652 Free PMC article.

7

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

Arkin MR, Tang Y, Wells JA. Arkin MR, et al. Among authors: wells ja. Chem Biol. 2014 Sep 18;21(9):1102-14. doi: 10.1016/j.chembiol.2014.09.001. Chem Biol. 2014. PMID: 25237857 Free PMC article. Review.

8

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.

Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. Rettenmaier TJ, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17. Proc Natl Acad Sci U S A. 2014. PMID: 25518860 Free PMC article.

9

Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling.

Morgan CW, Diaz JE, Zeitlin SG, Gray DC, Wells JA. Morgan CW, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8344-9. doi: 10.1073/pnas.1504141112. Epub 2015 Jun 23. Proc Natl Acad Sci U S A. 2015. PMID: 26106156 Free PMC article.

10

Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.

Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Julien O, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2001-10. doi: 10.1073/pnas.1524900113. Epub 2016 Mar 22. Proc Natl Acad Sci U S A. 2016. PMID: 27006500 Free PMC article.

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