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FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis.
Song L, Wang L, Hou Y, Zhou J, Chen C, Ye X, Dong W, Gao H, Liu Y, Qiao G, Pan T, Chen Q, Cao Y, Hu F, Rao Z, Chen Y, Han Y, Zheng M, Luo Y, Li X, Chen Y, Huang Z. Song L, et al. Among authors: chen q, chen c, chen y. Hepatology. 2022 Oct;76(4):1105-1120. doi: 10.1002/hep.32404. Epub 2022 Feb 27. Hepatology. 2022. PMID: 35152446
Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects.
Ying L, Wang L, Guo K, Hou Y, Li N, Wang S, Liu X, Zhao Q, Zhou J, Zhao L, Niu J, Chen C, Song L, Hou S, Kong L, Li X, Ren J, Li P, Mohammadi M, Huang Z. Ying L, et al. Among authors: chen c. Nat Commun. 2021 Dec 14;12(1):7256. doi: 10.1038/s41467-021-27584-y. Nat Commun. 2021. PMID: 34907199 Free PMC article.
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress.
Song L, Hou Y, Xu D, Dai X, Luo J, Liu Y, Huang Z, Yang M, Chen J, Hu Y, Chen C, Tang Y, Rao Z, Ma J, Zheng M, Shi K, Cai C, Lu M, Tang R, Ma X, Xie C, Luo Y, Li X, Huang Z. Song L, et al. Among authors: chen j, chen c. Cell Metab. 2024 Oct 4:S1550-4131(24)00372-3. doi: 10.1016/j.cmet.2024.09.008. Online ahead of print. Cell Metab. 2024. PMID: 39393353
Tumor Upstaging in Invasive Melanoma is Associated with Changes in Clinical Management and Worse Prognosis.
Rosenthal A, Kim JY, Juhasz ML, Conde G, Chen C, Eng S, Carrasco Mendoza CA, Chang CT, Ticknor I, Doan L, Schwarzmann KB, Garzione S, Li Y, Islas ZA, Gharavi NM, Man JR. Rosenthal A, et al. Among authors: chen c. J Am Acad Dermatol. 2024 Nov 21:S0190-9622(24)03233-X. doi: 10.1016/j.jaad.2024.11.028. Online ahead of print. J Am Acad Dermatol. 2024. PMID: 39579989
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