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PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression.
Tang H, Liang Y, Anders RA, Taube JM, Qiu X, Mulgaonkar A, Liu X, Harrington SM, Guo J, Xin Y, Xiong Y, Nham K, Silvers W, Hao G, Sun X, Chen M, Hannan R, Qiao J, Dong H, Peng H, Fu YX. Tang H, et al. Among authors: dong h. J Clin Invest. 2018 Feb 1;128(2):580-588. doi: 10.1172/JCI96061. Epub 2018 Jan 16. J Clin Invest. 2018. PMID: 29337303 Free PMC article.
PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy.
Tu X, Qin B, Zhang Y, Zhang C, Kahila M, Nowsheen S, Yin P, Yuan J, Pei H, Li H, Yu J, Song Z, Zhou Q, Zhao F, Liu J, Zhang C, Dong H, Mutter RW, Lou Z. Tu X, et al. Among authors: dong h. Mol Cell. 2019 Jun 20;74(6):1215-1226.e4. doi: 10.1016/j.molcel.2019.04.005. Epub 2019 Apr 30. Mol Cell. 2019. PMID: 31053471 Free PMC article.
Circulating levels of PD-L1 and Galectin-9 are associated with patient survival in surgically treated Hepatocellular Carcinoma independent of their intra-tumoral expression levels.
Sideras K, de Man RA, Harrington SM, Polak WG, Zhou G, Schutz HM, Pedroza-Gonzalez A, Biermann K, Mancham S, Hansen BE, Bart Takkenberg R, van Vuuren AJ, Pan Q, Ijzermans JNM, Sleijfer S, Sprengers D, Dong H, Kwekkeboom J, Bruno MJ. Sideras K, et al. Among authors: dong h. Sci Rep. 2019 Jul 23;9(1):10677. doi: 10.1038/s41598-019-47235-z. Sci Rep. 2019. PMID: 31337865 Free PMC article.
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