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Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR. Mettananda S, et al. Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7. Nat Commun. 2017. PMID: 28871148 Free PMC article.
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.
Oudelaar AM, Davies JOJ, Hanssen LLP, Telenius JM, Schwessinger R, Liu Y, Brown JM, Downes DJ, Chiariello AM, Bianco S, Nicodemi M, Buckle VJ, Dekker J, Higgs DR, Hughes JR. Oudelaar AM, et al. Among authors: downes dj. Nat Genet. 2018 Dec;50(12):1744-1751. doi: 10.1038/s41588-018-0253-2. Epub 2018 Oct 29. Nat Genet. 2018. PMID: 30374068 Free PMC article.
High-Throughput Genotyping of CRISPR/Cas Edited Cells in 96-Well Plates.
Nussbaum L, Telenius JM, Hill S, Hirschfeld PP, Suciu MC; WIGWAM Consortium; Downes DJ, Hughes JR. Nussbaum L, et al. Among authors: downes dj. Methods Protoc. 2018 Aug 1;1(3):29. doi: 10.3390/mps1030029. Methods Protoc. 2018. PMID: 31164571 Free PMC article.
Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis.
Gillespie MA, Palii CG, Sanchez-Taltavull D, Shannon P, Longabaugh WJR, Downes DJ, Sivaraman K, Espinoza HM, Hughes JR, Price ND, Perkins TJ, Ranish JA, Brand M. Gillespie MA, et al. Among authors: downes dj. Mol Cell. 2020 Jun 4;78(5):960-974.e11. doi: 10.1016/j.molcel.2020.03.031. Epub 2020 Apr 23. Mol Cell. 2020. PMID: 32330456 Free PMC article.
46 results