Spring DR - Search Results

1

Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability.

Walsh SJ, Omarjee S, Dannheim FM, Couturier DL, Bexheti D, Mendil L, Cronshaw G, Fewster T, Gregg C, Brodie C, Miller JL, Houghton R, Carroll JS, Spring DR. Walsh SJ, et al. Among authors: spring dr. Chem Commun (Camb). 2022 Feb 8;58(12):1962-1965. doi: 10.1039/d1cc06766d. Chem Commun (Camb). 2022. PMID: 35044383 Free PMC article.

2

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

Wyatt EE, Galloway WR, Thomas GL, Welch M, Loiseleur O, Plowright AT, Spring DR. Wyatt EE, et al. Among authors: spring dr. Chem Commun (Camb). 2008 Oct 28;(40):4962-4. doi: 10.1039/b812901k. Epub 2008 Sep 10. Chem Commun (Camb). 2008. PMID: 18931753

3

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst.

Kwan TT, Boutureira O, Frye EC, Walsh SJ, Gupta MK, Wallace S, Wu Y, Zhang F, Sore HF, Galloway WRJD, Chin JW, Welch M, Bernardes GJL, Spring DR. Kwan TT, et al. Among authors: spring dr. Chem Sci. 2017 May 1;8(5):3871-3878. doi: 10.1039/c6sc05313k. Epub 2017 Mar 14. Chem Sci. 2017. PMID: 28966779 Free PMC article.

4

Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.

Wu Y, Kaur A, Fowler E, Wiedmann MM, Young R, Galloway WRJD, Olsen L, Sore HF, Chattopadhyay A, Kwan TT, Xu W, Walsh SJ, de Andrade P, Janecek M, Arumugam S, Itzhaki LS, Lau YH, Spring DR. Wu Y, et al. Among authors: spring dr. ACS Chem Biol. 2019 Mar 15;14(3):526-533. doi: 10.1021/acschembio.9b00063. Epub 2019 Feb 7. ACS Chem Biol. 2019. PMID: 30702850

5

A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates.

Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. Walsh SJ, et al. Among authors: spring dr. Chem Sci. 2018 Nov 9;10(3):694-700. doi: 10.1039/c8sc04645j. eCollection 2019 Jan 21. Chem Sci. 2018. PMID: 30774870 Free PMC article.

6

Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates.

Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. Walsh SJ, et al. Among authors: spring dr. Chem Sci. 2018 Dec 13;10(2):633-634. doi: 10.1039/c8sc90248h. eCollection 2019 Jan 14. Chem Sci. 2018. PMID: 30778404 Free PMC article.

7

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.

Charoenpattarapreeda J, Tan YS, Iegre J, Walsh SJ, Fowler E, Eapen RS, Wu Y, Sore HF, Verma CS, Itzhaki L, Spring DR. Charoenpattarapreeda J, et al. Among authors: spring dr. Chem Commun (Camb). 2019 Jul 14;55(55):7914-7917. doi: 10.1039/c9cc04022f. Epub 2019 Jun 21. Chem Commun (Camb). 2019. PMID: 31225847

8

Cleavable linkers in antibody-drug conjugates.

Bargh JD , Isidro-Llobet A , Parker JS , Spring DR . Bargh JD , et al. Among authors: spring dr. Chem Soc Rev. 2019 Aug 12;48(16):4361-4374. doi: 10.1039/c8cs00676h. Chem Soc Rev. 2019. PMID: 31294429 Review.

9

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.

Robertson NS , Walsh SJ , Fowler E , Yoshida M , Rowe SM , Wu Y , Sore HF , Parker JS , Spring DR . Robertson NS , et al. Among authors: spring dr. Chem Commun (Camb). 2019 Aug 7;55(64):9499-9502. doi: 10.1039/c9cc05042f. Chem Commun (Camb). 2019. PMID: 31328756

10

Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.

Pettigrew TR, Porter RJ, Walsh SJ, Housden MP, Lam NYS, Carroll JS, Parker JS, Spring DR, Paterson I. Pettigrew TR, et al. Among authors: spring dr. Chem Commun (Camb). 2020 Feb 4;56(10):1529-1532. doi: 10.1039/c9cc09050a. Epub 2020 Jan 10. Chem Commun (Camb). 2020. PMID: 31922172

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