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Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity.
Bartoli F, Debant M, Chuntharpursat-Bon E, Evans EL, Musialowski KE, Parsonage G, Morley LC, Futers TS, Sukumar P, Bowen TS, Kearney MT, Lichtenstein L, Roberts LD, Beech DJ. Bartoli F, et al. Among authors: morley lc. J Clin Invest. 2022 Mar 1;132(5):e141775. doi: 10.1172/JCI141775. J Clin Invest. 2022. PMID: 35025768 Free PMC article.
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ. Rode B, et al. Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3. Nat Commun. 2017. PMID: 28839146 Free PMC article.
Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.
Endesh N, Chuntharpursat-Bon E, Revill C, Yuldasheva NY, Futers TS, Parsonage G, Humphreys N, Adamson A, Morley LC, Cubbon RM, Prasad KR, Foster R, Lichtenstein L, Beech DJ. Endesh N, et al. Among authors: morley lc. Liver Int. 2023 Sep;43(9):2026-2038. doi: 10.1111/liv.15646. Epub 2023 Jun 22. Liver Int. 2023. PMID: 37349903 Free PMC article.
Pharmacology of PIEZO1 channels.
Kinsella JA, Debant M, Parsonage G, Morley LC, Bajarwan M, Revill C, Foster R, Beech DJ. Kinsella JA, et al. Among authors: morley lc. Br J Pharmacol. 2024 Dec;181(23):4714-4732. doi: 10.1111/bph.17351. Epub 2024 Oct 14. Br J Pharmacol. 2024. PMID: 39402010 Review.
Maternal Cardiac Changes in Women With Obesity and Gestational Diabetes Mellitus.
Thirunavukarasu S, Ansari F, Cubbon R, Forbes K, Bucciarelli-Ducci C, Newby DE, Dweck MR, Rider OJ, Valkovič L, Rodgers CT, Tyler DJ, Chowdhary A, Jex N, Kotha S, Morley L, Xue H, Swoboda P, Kellman P, Greenwood JP, Plein S, Everett T, Scott E, Levelt E. Thirunavukarasu S, et al. Diabetes Care. 2022 Dec 1;45(12):3007-3015. doi: 10.2337/dc22-0401. Diabetes Care. 2022. PMID: 36099225 Free PMC article.
19 results