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Page 1
Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, Kiosses WB, Fan Z, Wen L, Jung Y, Roy P, Ali AJ, Miyamoto Y, Mangan M, Makings J, Wang Z, Denn A, Vallejo J, Owens M, Durant CP, Braumann S, Mader N, Li L, Matsunami H, Eckmann L, Latz E, Wang Z, Hazen SL, Ley K. Orecchioni M, et al. Among authors: latz e. Science. 2022 Jan 14;375(6577):214-221. doi: 10.1126/science.abg3067. Epub 2022 Jan 13. Science. 2022. PMID: 35025664 Free PMC article.
NLRP3 inflammasomes link inflammation and metabolic disease.
De Nardo D, Latz E. De Nardo D, et al. Among authors: latz e. Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/j.it.2011.05.004. Epub 2011 Jul 4. Trends Immunol. 2011. PMID: 21733753 Free PMC article. Review.
NLRC3 puts the brakes on STING.
Mangan MS, Latz E. Mangan MS, et al. Among authors: latz e. Immunity. 2014 Mar 20;40(3):305-6. doi: 10.1016/j.immuni.2014.02.007. Immunity. 2014. PMID: 24656040 Free PMC article.
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E. Franklin BS, et al. Among authors: latz e. Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22. Nat Immunol. 2014. PMID: 24952505 Free PMC article.
Crystal Formation in Inflammation.
Franklin BS, Mangan MS, Latz E. Franklin BS, et al. Among authors: latz e. Annu Rev Immunol. 2016 May 20;34:173-202. doi: 10.1146/annurev-immunol-041015-055539. Epub 2016 Jan 11. Annu Rev Immunol. 2016. PMID: 26772211 Review.
Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP. Primiano MJ, et al. Among authors: latz e. J Immunol. 2016 Sep 15;197(6):2421-33. doi: 10.4049/jimmunol.1600035. Epub 2016 Aug 12. J Immunol. 2016. PMID: 27521339
Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
Scheiblich H, Schlütter A, Golenbock DT, Latz E, Martinez-Martinez P, Heneka MT. Scheiblich H, et al. Among authors: latz e. J Neurochem. 2017 Dec;143(5):534-550. doi: 10.1111/jnc.14225. Epub 2017 Oct 26. J Neurochem. 2017. PMID: 28940479 Free article.
TAK1ng control: TAK1 restrains NLRP3 activation.
Mangan MS, Latz E. Mangan MS, et al. Among authors: latz e. J Exp Med. 2018 Apr 2;215(4):1007-1008. doi: 10.1084/jem.20180282. Epub 2018 Mar 5. J Exp Med. 2018. PMID: 29507056 Free PMC article.
336 results