Frances N - Search Results

1

Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab.

Frances N, Bacac M, Bray-French K, Christen F, Hinton H, Husar E, Quackenbush E, Schäfer M, Schick E, Vyver AV, Richter WF. Frances N, et al. J Pharm Sci. 2022 Apr;111(4):1208-1218. doi: 10.1016/j.xphs.2021.12.019. Epub 2021 Dec 22. J Pharm Sci. 2022. PMID: 34953862

2

Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice.

Richter WF, Christianson GJ, Frances N, Grimm HP, Proetzel G, Roopenian DC. Richter WF, et al. Among authors: frances n. MAbs. 2018 Jul;10(5):803-813. doi: 10.1080/19420862.2018.1458808. Epub 2018 May 9. MAbs. 2018. PMID: 29621428 Free PMC article.

3

Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling.

Van De Vyver AJ, Weinzierl T, Eigenmann MJ, Frances N, Herter S, Buser RB, Somandin J, Diggelmann S, Limani F, Lehr T, Bacac M, Walz AC. Van De Vyver AJ, et al. Among authors: frances n. Mol Cancer Ther. 2021 Feb;20(2):357-366. doi: 10.1158/1535-7163.MCT-20-0269. Epub 2020 Dec 9. Mol Cancer Ther. 2021. PMID: 33298591

4

Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor.

Wichmann J, Rynn C, Friess T, Petrig-Schaffland J, Kornacker M, Handl C, Emmenegger J, Eckmann J, Herting F, Frances N, Hunziker D, Krummenacher D, Rüttinger D, Ribeiro A, Bacac M, Brigo A, Hewings DS, Dummer R, Levesque MP, Schnetzler G, Martoglio B, Bischoff JR, Pettazzoni P. Wichmann J, et al. Among authors: frances n. Clin Cancer Res. 2022 Feb 15;28(4):770-780. doi: 10.1158/1078-0432.CCR-21-2761. Clin Cancer Res. 2022. PMID: 34782366

5

Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development.

Caruso A, Frances N, Meille C, Greiter-Wilke A, Hillebrecht A, Lavé T. Caruso A, et al. Among authors: frances n. J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):73-85. doi: 10.1016/j.vascn.2014.05.004. Epub 2014 May 28. J Pharmacol Toxicol Methods. 2014. PMID: 24879942

6

Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1.

Sánchez J, Nicolini V, Fahrni L, Waldhauer I, Walz AC, Jamois C, Fowler S, Simon S, Klein C, Umaña P, Friberg LE, Frances N. Sánchez J, et al. Among authors: frances n. AAPS J. 2022 Oct 7;24(6):106. doi: 10.1208/s12248-022-00755-5. AAPS J. 2022. PMID: 36207642

7

Combining Nonclinical Experiments with Translational PKPD Modeling to Differentiate Erlotinib and Gefitinib.

Eigenmann MJ, Frances N, Hoffmann G, Lavé T, Walz AC. Eigenmann MJ, et al. Among authors: frances n. Mol Cancer Ther. 2016 Dec;15(12):3110-3119. doi: 10.1158/1535-7163.MCT-16-0076. Epub 2016 Sep 16. Mol Cancer Ther. 2016. PMID: 27638857

8

Time-to-Event Analysis of Paclitaxel-Associated Peripheral Neuropathy in Advanced Non-Small-Cell Lung Cancer Highlighting Key Influential Treatment/Patient Factors.

Ojara FW, Henrich A, Frances N, Huisinga W, Hartung N, Joerger M, Kloft C. Ojara FW, et al. Among authors: frances n. J Pharmacol Exp Ther. 2020 Dec;375(3):430-438. doi: 10.1124/jpet.120.000053. Epub 2020 Oct 2. J Pharmacol Exp Ther. 2020. PMID: 33008871

9

An interface model for dosage adjustment connects hematotoxicity to pharmacokinetics.

Meille C, Iliadis A, Barbolosi D, Frances N, Freyer G. Meille C, et al. Among authors: frances n. J Pharmacokinet Pharmacodyn. 2008 Dec;35(6):619-33. doi: 10.1007/s10928-008-9106-4. Epub 2008 Dec 24. J Pharmacokinet Pharmacodyn. 2008. PMID: 19107581

10

PKPD modeling of acquired resistance to anti-cancer drug treatment.

Eigenmann MJ, Frances N, Lavé T, Walz AC. Eigenmann MJ, et al. Among authors: frances n. J Pharmacokinet Pharmacodyn. 2017 Dec;44(6):617-630. doi: 10.1007/s10928-017-9553-x. Epub 2017 Oct 31. J Pharmacokinet Pharmacodyn. 2017. PMID: 29090407 Free PMC article.

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