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Biparatopic nanobodies protect mice from lethal challenge with SARS-CoV-2 variants of concern.
Wagner TR, Schnepf D, Beer J, Ruetalo N, Klingel K, Kaiser PD, Junker D, Sauter M, Traenkle B, Frecot DI, Becker M, Schneiderhan-Marra N, Ohnemus A, Schwemmle M, Schindler M, Rothbauer U. Wagner TR, et al. Among authors: schwemmle m. EMBO Rep. 2022 Feb 3;23(2):e53865. doi: 10.15252/embr.202153865. Epub 2021 Dec 20. EMBO Rep. 2022. PMID: 34927793 Free PMC article.
Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses.
Schnepf D, Crotta S, Thamamongood T, Stanifer M, Polcik L, Ohnemus A, Vier J, Jakob C, Llorian M, Gad HH, Hartmann R, Strobl B, Kirschnek S, Boulant S, Schwemmle M, Wack A, Staeheli P. Schnepf D, et al. Among authors: schwemmle m. Sci Immunol. 2021 May 14;6(59):eabd5318. doi: 10.1126/sciimmunol.abd5318. Sci Immunol. 2021. PMID: 33990378 Free PMC article.
An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models.
Schepens B, van Schie L, Nerinckx W, Roose K, Van Breedam W, Fijalkowska D, Devos S, Weyts W, De Cae S, Vanmarcke S, Lonigro C, Eeckhaut H, Van Herpe D, Borloo J, Oliveira AF, Catani JPP, Creytens S, De Vlieger D, Michielsen G, Marchan JCZ, Moschonas GD, Rossey I, Sedeyn K, Van Hecke A, Zhang X, Langendries L, Jacobs S, Ter Horst S, Seldeslachts L, Liesenborghs L, Boudewijns R, Thibaut HJ, Dallmeier K, Velde GV, Weynand B, Beer J, Schnepf D, Ohnemus A, Remory I, Foo CS, Abdelnabi R, Maes P, Kaptein SJF, Rocha-Pereira J, Jochmans D, Delang L, Peelman F, Staeheli P, Schwemmle M, Devoogdt N, Tersago D, Germani M, Heads J, Henry A, Popplewell A, Ellis M, Brady K, Turner A, Dombrecht B, Stortelers C, Neyts J, Callewaert N, Saelens X. Schepens B, et al. Among authors: schwemmle m. Sci Transl Med. 2021 Nov 24;13(621):eabi7826. doi: 10.1126/scitranslmed.abi7826. Epub 2021 Nov 24. Sci Transl Med. 2021. PMID: 34609205 Free PMC article.
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants.
Weigang S, Fuchs J, Zimmer G, Schnepf D, Kern L, Beer J, Luxenburger H, Ankerhold J, Falcone V, Kemming J, Hofmann M, Thimme R, Neumann-Haefelin C, Ulferts S, Grosse R, Hornuss D, Tanriver Y, Rieg S, Wagner D, Huzly D, Schwemmle M, Panning M, Kochs G. Weigang S, et al. Among authors: schwemmle m. Nat Commun. 2021 Nov 4;12(1):6405. doi: 10.1038/s41467-021-26602-3. Nat Commun. 2021. PMID: 34737266 Free PMC article.
Antibody escape and global spread of SARS-CoV-2 lineage A.27.
Kaleta T, Kern L, Hong SL, Hölzer M, Kochs G, Beer J, Schnepf D, Schwemmle M, Bollen N, Kolb P, Huber M, Ulferts S, Weigang S, Dudas G, Wittig A, Jaki L, Padane A, Lagare A, Salou M, Ozer EA, Nnaemeka N, Odoom JK, Rutayisire R, Benkahla A, Akoua-Koffi C, Ouedraogo AS, Simon-Lorière E, Enouf V, Kröger S, Calvignac-Spencer S, Baele G, Panning M, Fuchs J. Kaleta T, et al. Among authors: schwemmle m. Nat Commun. 2022 Mar 3;13(1):1152. doi: 10.1038/s41467-022-28766-y. Nat Commun. 2022. PMID: 35241661 Free PMC article.
Impaired immune response drives age-dependent severity of COVID-19.
Beer J, Crotta S, Breithaupt A, Ohnemus A, Becker J, Sachs B, Kern L, Llorian M, Ebert N, Labroussaa F, Nhu Thao TT, Trueeb BS, Jores J, Thiel V, Beer M, Fuchs J, Kochs G, Wack A, Schwemmle M, Schnepf D. Beer J, et al. Among authors: schwemmle m. J Exp Med. 2022 Dec 5;219(12):e20220621. doi: 10.1084/jem.20220621. Epub 2022 Sep 21. J Exp Med. 2022. PMID: 36129445 Free PMC article.
Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient.
Jaki L, Weigang S, Kern L, Kramme S, Wrobel AG, Grawitz AB, Nawrath P, Martin SR, Dähne T, Beer J, Disch M, Kolb P, Gutbrod L, Reuter S, Warnatz K, Schwemmle M, Gamblin SJ, Neumann-Haefelin E, Schnepf D, Welte T, Kochs G, Huzly D, Panning M, Fuchs J. Jaki L, et al. Among authors: schwemmle m. Nat Commun. 2023 Apr 10;14(1):1999. doi: 10.1038/s41467-023-37591-w. Nat Commun. 2023. PMID: 37037847 Free PMC article.
Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells.
Schulien I, Kemming J, Oberhardt V, Wild K, Seidel LM, Killmer S, Sagar, Daul F, Salvat Lago M, Decker A, Luxenburger H, Binder B, Bettinger D, Sogukpinar O, Rieg S, Panning M, Huzly D, Schwemmle M, Kochs G, Waller CF, Nieters A, Duerschmied D, Emmerich F, Mei HE, Schulz AR, Llewellyn-Lacey S, Price DA, Boettler T, Bengsch B, Thimme R, Hofmann M, Neumann-Haefelin C. Schulien I, et al. Among authors: schwemmle m. Nat Med. 2021 Jan;27(1):78-85. doi: 10.1038/s41591-020-01143-2. Epub 2020 Nov 12. Nat Med. 2021. PMID: 33184509
Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany.
Tönshoff B, Müller B, Elling R, Renk H, Meissner P, Hengel H, Garbade SF, Kieser M, Jeltsch K, Grulich-Henn J, Euler J, Stich M, Chobanyan-Jürgens K, Zernickel M, Janda A, Wölfle L, Stamminger T, Iftner T, Ganzenmueller T, Schmitt C, Görne T, Laketa V, Olberg S, Plaszczyca A, Cortese M, Bartenschlager R, Pape C, Remme R, Huzly D, Panning M, Weigang S, Giese S, Ciminski K, Ankerhold J, Kochs G, Schwemmle M, Handgretinger R, Niemeyer CM, Engel C, Kern WV, Hoffmann GF, Franz AR, Henneke P, Debatin KM, Kräusslich HG. Tönshoff B, et al. Among authors: schwemmle m. JAMA Pediatr. 2021 Jun 1;175(6):586-593. doi: 10.1001/jamapediatrics.2021.0001. JAMA Pediatr. 2021. PMID: 33480966 Free PMC article.
Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine.
Oberhardt V, Luxenburger H, Kemming J, Schulien I, Ciminski K, Giese S, Csernalabics B, Lang-Meli J, Janowska I, Staniek J, Wild K, Basho K, Marinescu MS, Fuchs J, Topfstedt F, Janda A, Sogukpinar O, Hilger H, Stete K, Emmerich F, Bengsch B, Waller CF, Rieg S, Sagar, Boettler T, Zoldan K, Kochs G, Schwemmle M, Rizzi M, Thimme R, Neumann-Haefelin C, Hofmann M. Oberhardt V, et al. Among authors: schwemmle m. Nature. 2021 Sep;597(7875):268-273. doi: 10.1038/s41586-021-03841-4. Epub 2021 Jul 28. Nature. 2021. PMID: 34320609 Free PMC article.
199 results