Zhang L - Search Results

1

Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.

Zhao P, Zhuang L, Wang X, Huang S, Wu H, Zhou Y, Yan Y, Zhang F, Shen R, Li J, Liu S, Zhang R, Dong P, Mao Y, Fan Y, He C, Sun J, Zhang L, Hu Q, Wan H, Feng J, Bai C, He F, Tao W. Zhao P, et al. Among authors: zhang l, zhang r, zhang f. Eur J Med Chem. 2022 Jan 15;228:114040. doi: 10.1016/j.ejmech.2021.114040. Epub 2021 Dec 7. Eur J Med Chem. 2022. PMID: 34906761

2

Discovery of SHR2415, a Novel Pyrrole-Fused Urea Scaffold ERK1/2 Inhibitor.

Li X, Dong P, Zhang T, Cai G, Chen Y, Dong H, Yang F, Zhang L, Mao Y, Feng J, Bai C, He F, Tao W. Li X, et al. Among authors: zhang l, zhang t. ACS Med Chem Lett. 2022 Apr 1;13(4):701-706. doi: 10.1021/acsmedchemlett.2c00029. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450372 Free PMC article.

3

Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model.

Peng J, Hu Q, Gu C, Liu B, Jin F, Yuan J, Feng J, Zhang L, Lan J, Dong Q, Cao G. Peng J, et al. Among authors: zhang l. Bioorg Med Chem Lett. 2016 Jan 15;26(2):277-282. doi: 10.1016/j.bmcl.2015.12.040. Epub 2015 Dec 12. Bioorg Med Chem Lett. 2016. PMID: 26704267

4

Synthesis and bioevaluation of 1-phenylimidazole-4-carboxylic acid derivatives as novel xanthine oxidoreductase inhibitors.

Zhou H, Li X, Li Y, Zhu X, Zhang L, Li J. Zhou H, et al. Among authors: zhang l. Eur J Med Chem. 2020 Jan 15;186:111883. doi: 10.1016/j.ejmech.2019.111883. Epub 2019 Nov 15. Eur J Med Chem. 2020. PMID: 31761385

5

SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.

Song C, Liu D, Liu S, Li D, Horecny I, Zhang X, Li P, Chen L, Miller M, Chowdhury R, Issa M, Shen R, Yan Y, Zhang F, Zhang L, Zhang L, Bai C, Feng J, Zhuang L, Zhang R, Li J, Wilkinson H, Liu J, Tao W. Song C, et al. Among authors: zhang l, zhang r, zhang f, zhang x. Sci Rep. 2022 May 20;12(1):8579. doi: 10.1038/s41598-022-12449-1. Sci Rep. 2022. PMID: 35595822 Free PMC article.

6

Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.

Cui S, Wang Y, Wang Y, Tang X, Ren X, Zhang L, Xu Y, Zhang Z, Zhang ZM, Lu X, Ding K. Cui S, et al. Among authors: zhang l, zhang z, zhang zm. Eur J Med Chem. 2019 Oct 1;179:470-482. doi: 10.1016/j.ejmech.2019.06.064. Epub 2019 Jun 25. Eur J Med Chem. 2019. PMID: 31271959

7

Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.

Ji X, Xia C, Wang J, Su M, Zhang L, Dong T, Li Z, Wan X, Li J, Li J, Zhao L, Gao Z, Jiang H, Liu H. Ji X, et al. Among authors: zhang l. Eur J Med Chem. 2014 Oct 30;86:242-56. doi: 10.1016/j.ejmech.2014.08.059. Epub 2014 Aug 19. Eur J Med Chem. 2014. PMID: 25164763

8

Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.

Xue ST, Zhang L, Xie ZS, Jin J, Guo HF, Yi H, Liu ZY, Li ZR. Xue ST, et al. Among authors: zhang l. Eur J Med Chem. 2020 Aug 15;200:112465. doi: 10.1016/j.ejmech.2020.112465. Epub 2020 May 16. Eur J Med Chem. 2020. PMID: 32480301

9

Synthesis and evaluation of tetrahydroquinolin-2(1H)-one derivatives as novel anti-pancreatic cancer agents via targeting autophagy.

Shen Q, Wang J, Liu CX, Cui W, Zhang L, Zhang YC, Wang Y, Wu J, Li JX. Shen Q, et al. Among authors: zhang l, zhang yc. Eur J Med Chem. 2019 May 15;170:28-44. doi: 10.1016/j.ejmech.2019.03.013. Epub 2019 Mar 9. Eur J Med Chem. 2019. PMID: 30878830

10

Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.

Feng Y, Zhang B, Lv J, Zhang P, Mao Q, Lin F, Zhao J, Fu X, Yang Y, Li Z, Zhang L, Mou Y, Wang S. Feng Y, et al. Among authors: zhang l, zhang b, zhang p. Eur J Med Chem. 2022 Apr 15;234:114254. doi: 10.1016/j.ejmech.2022.114254. Epub 2022 Mar 9. Eur J Med Chem. 2022. PMID: 35290844

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