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Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.
Zhao P, Zhuang L, Wang X, Huang S, Wu H, Zhou Y, Yan Y, Zhang F, Shen R, Li J, Liu S, Zhang R, Dong P, Mao Y, Fan Y, He C, Sun J, Zhang L, Hu Q, Wan H, Feng J, Bai C, He F, Tao W. Zhao P, et al. Among authors: zhang l, zhang r, zhang f. Eur J Med Chem. 2022 Jan 15;228:114040. doi: 10.1016/j.ejmech.2021.114040. Epub 2021 Dec 7. Eur J Med Chem. 2022. PMID: 34906761
Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways.
Zhou Y, Li X, Shen R, Wang X, Zhang F, Liu S, Li D, Liu J, Li P, Yan Y, Dong P, Zhang Z, Wu H, Zhuang L, Chowdhury R, Miller M, Issa M, Mao Y, Chen H, Feng J, Li J, Bai C, He F, Tao W. Zhou Y, et al. Among authors: zhang f, zhang z. Front Immunol. 2022 May 20;13:884399. doi: 10.3389/fimmu.2022.884399. eCollection 2022. Front Immunol. 2022. PMID: 35693820 Free PMC article.
Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2.
Guo Y, Xue H, Hu N, Liu Y, Sun H, Yu D, Qin L, Shi G, Wang F, Xin L, Sun W, Zhang F, Song X, Li S, Wei Q, Guo Y, Li Y, Liu X, Chen S, Zhang T, Wu Y, Su D, Zhu Y, Xu A, Xu H, Yang S, Zheng Z, Liu J, Yang X, Yuan X, Hong Y, Sun X, Guo Y, Zhou C, Liu X, Wang L, Wang Z. Guo Y, et al. Among authors: zhang f, zhang t. J Med Chem. 2024 May 23;67(10):7836-7858. doi: 10.1021/acs.jmedchem.4c00027. Epub 2024 May 2. J Med Chem. 2024. PMID: 38695063 Free PMC article.
Discovery and Evaluation of TLR-Targeted Immune Agonists.
Chernyak N, Bhagwat B, Naravula S, Chen Y, Solban N, Zhang F, Kofman E, Raoufi F, Dang X, Bao J, Tomazela D, Baily M, Geierstanger B, Flygare JA, Han JH, Willingham A, Seganish WM. Chernyak N, et al. Among authors: zhang f. J Med Chem. 2024 Sep 26;67(18):16222-16234. doi: 10.1021/acs.jmedchem.4c00804. Epub 2024 Sep 5. J Med Chem. 2024. PMID: 39235949
Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads.
Patel AM, Willingham A, Cheng AC, Tomazela D, Bowman E, Kofman E, Zhang F, Bao J, Sanzone JR, Choy JW, Flygare JA, Han JH, Pradhan K, Kieffer M, Chernyak N, Akbari P, Liu P, Mehmood R, Naravula S, Hollingsworth SA, Bhagwat B, Lang SB, Seganish WM. Patel AM, et al. Among authors: zhang f. J Med Chem. 2024 Sep 12;67(17):15756-15779. doi: 10.1021/acs.jmedchem.4c01384. Epub 2024 Aug 22. J Med Chem. 2024. PMID: 39172064
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