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Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.
Zhao P, Zhuang L, Wang X, Huang S, Wu H, Zhou Y, Yan Y, Zhang F, Shen R, Li J, Liu S, Zhang R, Dong P, Mao Y, Fan Y, He C, Sun J, Zhang L, Hu Q, Wan H, Feng J, Bai C, He F, Tao W. Zhao P, et al. Among authors: mao y. Eur J Med Chem. 2022 Jan 15;228:114040. doi: 10.1016/j.ejmech.2021.114040. Epub 2021 Dec 7. Eur J Med Chem. 2022. PMID: 34906761
Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity.
Lu B, Liu D, Gui B, Gou J, Dong H, Hu Q, Feng J, Mao Y, Shen X, Wang S, Zhang C, Shen R, Yan Y, Chen L, Wang H, Li D, Zhang J, Zhang M, Zhang R, Bai C, He F, Tao W, Liu S. Lu B, et al. Among authors: mao y. J Med Chem. 2021 Oct 28;64(20):14983-14996. doi: 10.1021/acs.jmedchem.1c00828. Epub 2021 Oct 13. J Med Chem. 2021. PMID: 34643383
Discovery of SHR5133, a Highly Potent and Novel HBV Capsid Assembly Modulator.
Li X, Zhang Z, Chen Y, Wang B, Yang G, Xu X, Yechao B, Bai D, Feng B, Mao Y, Feng J, Bai C, He F, Tao W. Li X, et al. Among authors: mao y. ACS Med Chem Lett. 2022 Feb 17;13(3):507-512. doi: 10.1021/acsmedchemlett.2c00002. eCollection 2022 Mar 10. ACS Med Chem Lett. 2022. PMID: 35300087 Free PMC article.
Discovery of SHR2415, a Novel Pyrrole-Fused Urea Scaffold ERK1/2 Inhibitor.
Li X, Dong P, Zhang T, Cai G, Chen Y, Dong H, Yang F, Zhang L, Mao Y, Feng J, Bai C, He F, Tao W. Li X, et al. Among authors: mao y. ACS Med Chem Lett. 2022 Apr 1;13(4):701-706. doi: 10.1021/acsmedchemlett.2c00029. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450372 Free PMC article.
Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways.
Zhou Y, Li X, Shen R, Wang X, Zhang F, Liu S, Li D, Liu J, Li P, Yan Y, Dong P, Zhang Z, Wu H, Zhuang L, Chowdhury R, Miller M, Issa M, Mao Y, Chen H, Feng J, Li J, Bai C, He F, Tao W. Zhou Y, et al. Among authors: mao y. Front Immunol. 2022 May 20;13:884399. doi: 10.3389/fimmu.2022.884399. eCollection 2022. Front Immunol. 2022. PMID: 35693820 Free PMC article.
Discovery of Isoindoline Amide Derivatives as Potent and Orally Bioavailable ADAMTS-4/5 Inhibitors for the Treatment of Osteoarthritis.
Zhao P, Liu D, Song C, Li D, Zhang X, Horecny I, Zhang F, Yan Y, Zhuang L, Li J, Liu S, Mao Y, Feng J, Liu J, Tao W. Zhao P, et al. Among authors: mao y. ACS Pharmacol Transl Sci. 2022 Jun 22;5(7):458-467. doi: 10.1021/acsptsci.2c00023. eCollection 2022 Jul 8. ACS Pharmacol Transl Sci. 2022. PMID: 35837136 Free PMC article.
Discovery of SHR5428 as a selective and noncovalent inhibitor of CDK7.
Jia M, Wang W, Chen G, Wu T, Zhang T, Zhou Q, Yin J, Li J, Li X, Mao Y, Feng J, Hu M, Li X, He F. Jia M, et al. Among authors: mao y. Bioorg Med Chem Lett. 2023 Sep 1;93:129429. doi: 10.1016/j.bmcl.2023.129429. Epub 2023 Aug 4. Bioorg Med Chem Lett. 2023. PMID: 37543274
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