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A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.
Rice S, Jackson T, Crump NT, Fordham N, Elliott N, O'Byrne S, Fanego MDML, Addy D, Crabb T, Dryden C, Inglott S, Ladon D, Wright G, Bartram J, Ancliff P, Mead AJ, Halsey C, Roberts I, Milne TA, Roy A. Rice S, et al. Among authors: roberts i. Nat Commun. 2021 Nov 25;12(1):6905. doi: 10.1038/s41467-021-27270-z. Nat Commun. 2021. PMID: 34824279 Free PMC article.
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.
Roy A, Cowan G, Mead AJ, Filippi S, Bohn G, Chaidos A, Tunstall O, Chan JK, Choolani M, Bennett P, Kumar S, Atkinson D, Wyatt-Ashmead J, Hu M, Stumpf MP, Goudevenou K, O'Connor D, Chou ST, Weiss MJ, Karadimitris A, Jacobsen SE, Vyas P, Roberts I. Roy A, et al. Among authors: roberts i. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17579-84. doi: 10.1073/pnas.1211405109. Epub 2012 Oct 8. Proc Natl Acad Sci U S A. 2012. PMID: 23045701 Free PMC article.
The impact of trisomy 21 on early human hematopoiesis.
Roy A, Cowan G, Vyas P, Roberts I. Roy A, et al. Among authors: roberts i. Cell Cycle. 2013 Feb 15;12(4):533-4. doi: 10.4161/cc.23667. Epub 2013 Jan 23. Cell Cycle. 2013. PMID: 23343767 Free PMC article. No abstract available.
The impact of trisomy 21 on foetal haematopoiesis.
Roberts I, O'Connor D, Roy A, Cowan G, Vyas P. Roberts I, et al. Blood Cells Mol Dis. 2013 Dec;51(4):277-81. doi: 10.1016/j.bcmd.2013.07.008. Epub 2013 Aug 7. Blood Cells Mol Dis. 2013. PMID: 23932236 Free PMC article. Review.
Stem and progenitor cell dysfunction in human trisomies.
Liu B, Filippi S, Roy A, Roberts I. Liu B, et al. Among authors: roberts i. EMBO Rep. 2015 Jan;16(1):44-62. doi: 10.15252/embr.201439583. Epub 2014 Dec 17. EMBO Rep. 2015. PMID: 25520324 Free PMC article. Review.
MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
Kerry J, Godfrey L, Repapi E, Tapia M, Blackledge NP, Ma H, Ballabio E, O'Byrne S, Ponthan F, Heidenreich O, Roy A, Roberts I, Konopleva M, Klose RJ, Geng H, Milne TA. Kerry J, et al. Among authors: roberts i. Cell Rep. 2017 Jan 10;18(2):482-495. doi: 10.1016/j.celrep.2016.12.054. Cell Rep. 2017. PMID: 28076791 Free PMC article.
1,560 results