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Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation.
Gu F, Krüger A, Roggenkamp HG, Alpers R, Lodygin D, Jaquet V, Möckl F, Hernandez C LC, Winterberg K, Bauche A, Rosche A, Grasberger H, Kao JY, Schetelig D, Werner R, Schröder K, Carty M, Bowie AG, Huber S, Meier C, Mittrücker HW, Heeren J, Krause KH, Flügel A, Diercks BP, Guse AH. Gu F, et al. Sci Signal. 2021 Nov 16;14(709):eabe3800. doi: 10.1126/scisignal.abe3800. Epub 2021 Nov 16. Sci Signal. 2021. PMID: 34784249
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation.
Roggenkamp HG, Khansahib I, Hernandez C LC, Zhang Y, Lodygin D, Krüger A, Gu F, Möckl F, Löhndorf A, Wolters V, Woike D, Rosche A, Bauche A, Schetelig D, Werner R, Schlüter H, Failla AV, Meier C, Fliegert R, Walseth TF, Flügel A, Diercks BP, Guse AH. Roggenkamp HG, et al. Among authors: gu f. Sci Signal. 2021 Mar 23;14(675):eabd5647. doi: 10.1126/scisignal.abd5647. Sci Signal. 2021. PMID: 33758062
2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.
Fliegert R, Bauche A, Wolf Pérez AM, Watt JM, Rozewitz MD, Winzer R, Janus M, Gu F, Rosche A, Harneit A, Flato M, Moreau C, Kirchberger T, Wolters V, Potter BVL, Guse AH. Fliegert R, et al. Among authors: gu f. Nat Chem Biol. 2017 Sep;13(9):1036-1044. doi: 10.1038/nchembio.2415. Epub 2017 Jun 26. Nat Chem Biol. 2017. PMID: 28671679 Free PMC article.
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[No authors listed] [No authors listed] PMID: 34890368
1,985 results