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Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6L.
Dominko K, Rastija A, Smiljanic K, Mladenovic A, Lešnjaković L, Kanazir S, Milanovic D, Hecimovic S. Dominko K, et al. Among authors: lesnjakovic l. Mech Ageing Dev. 2022 Oct;207:111726. doi: 10.1016/j.mad.2022.111726. Epub 2022 Aug 23. Mech Ageing Dev. 2022. PMID: 35998821